晚期早产儿神经发育预后及影响因素分析

Study on the neurological development and associated impacts of late preterm infants

目的:对比分析晚期早产儿及正常足月儿间神经发育情况的差异,探讨影响晚期早产儿神经发育异常的相关因素。方法:以我院妇产科分娩成功的晚期早产儿134例及同期正常分娩足月儿100例为研究对象,统计他们的一般资料并进行发育商测试,采用Logistic回归分析筛选影响晚期早产儿神经发育的危险因素。结果:除适应性及社会行为两项外,晚期早产儿组的大运动、精细动作、语言评分及DQ评分均显著降低(P<0.05);晚期早产儿组出现神经发育异常者9例,发生率为6.72%,较对照组(1.00%)显著升高(P<0.05);晚期早产儿神经发育异常与极低出生体重、低血糖、母亲文化程度低密切相关。结论:晚期早产儿神经发育水平较正常足月儿显著降低,极低出生体重、低血糖、父母文化程度低是影响其神经发育的主要因素。

Objective： To compare the difference of neurological development between late preterm and full-term infants and to explore the associated impacts of late preterm infants at 1 year old and 2 year old. Methods： A total of 134 late preterm infants and 100 full-term infants delivered at our hospital received assessments of ＂0 -6-year-old children intelligence development scale＂ for neurological development at 1 year old and 2 year old. Social-domestic and clinical factors related to neurological development were analyzed with Logistic regression. Results： The fine moment, strength exercises, language and DQ score of late preterm infants were significantly reduced except emotion and social behavior（P 〈0. 05）. Higher abnormal rate of low DQ was found among late preterm infants（6. 72% ） than normal infants （ 1.00% ） （P 〈 0. 05）. Very-low-birth-weight, hypoglycemia education level of mother were related to DQ scores of late preterm infants. Conclusion： The late preterm infants are much likely to suffer from neurological developmental delay. It is closely related to very-low-birth-weight, hypoglycemia education level of mother.