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视神经脊髓炎病人的血清尿酸水平与临床相关性的分析 被引量:2

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摘要 目的:探讨18例急性视神经脊髓炎(The optic nerve myelitis,NMO)病人血清尿酸水平与NMO病人的临床相关性。方法:回顾性分析2005~2013年鄂尔多斯市中心医院收治的18例视神经脊髓炎病人的血清尿酸水平并以同期年龄大致相同的22例健康体检者作为对照,比较2组研究对象的血清尿酸水平有无差异性。结果:NMO组病人血清尿酸[(248.06±76.17)umol/L]明显低于对照组[(318.40±77.30)umol/L],且有统计学意义(P值均〈0.05),视神经脊髓炎组尿酸在女性[(220.71±58.84)umol/L]与男性[(343.75±46.71)umol/L]、扩展残疾状态量表评分≥5分[(298.09±55.47)umol/L]与〈5分[(183.29±59.68)umol/L]、1a内复发[(278.67±144.57)umol/L]≥1a复发[(241.93±61.79)umol/L]的病人相比差异有统计学意义(P〈0.05),与病程、AQP 4阳性无关(P〉0.05)。结论:NMO组病人血清尿酸明显低于对照组,血尿酸减低可能是引起视神经脊髓炎的一个生物学标志的危险因素。
出处 《内蒙古医科大学学报》 2015年第1期66-68,共3页 Journal of Inner Mongolia Medical University
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  • 1Swanton JK, Rovira A, Tintore M, et al. Mri criteria for multiple sclerosis in patients presenting wim clinically isolated syndromes : a muhicentre retrospective study [ J ]. Lancet Neurol,2007 ;6(8) :677-686.
  • 2Lana-peixoto MA. Devic' s neuromyelitis optica : a critical review[J]. Arq Neuropsiquiatr,2008 ;66( 1 ) :120-138.
  • 3Matiello M, Lennon VA, Jacob A, et al. Nmo-igg predicts the outcome of recurrent optic neuritis [ J ]. Neurology,2008 ;70(23 ) :2197-2200.
  • 4Argyriou AA, Makris N. Neuromyelitis optica:a distinct de- myelinating disease of the central nervous system[ J]. Acta Neurol Seand,2008 ;118(4) :209-217.
  • 5Takahashi T, Fujihara K, Nakashima I, et al. Antiaquaporin -4antibody is involved in the pathogenesis of nmo:a study on antibody titre [ J ]. Brain,2007 ; 130 ( 5 ) : 1235-1243.
  • 6杨新光,何毅华,陈梦宇,殷建瑞,解龙昌,龙友明,张斌,高聪.早期多发性硬化和视神经脊髓炎高危综合征临床特点的比较[J].中华神经医学杂志,2013,12(8):790-793. 被引量:6
  • 7尤小凡,叶静,秦伟,赵文慧,郝咏刚,胡文立.视神经脊髓炎血清尿酸水平与临床相关性研究[J].中华内科杂志,2010,49(11):935-938. 被引量:6
  • 8尤小凡,秦伟,郝咏刚,赵文慧,叶静,胡文立.视神经脊髓炎高危综合征患者血清尿酸水平与临床特征的相关性[J].中华神经科杂志,2011,44(2):109-112. 被引量:3

二级参考文献51

  • 1Weinshenker BG.Neuromyelitis optica is distinct from multiple sclerosis.Arch Neurol,2007,64:899-901.
  • 2van der Veen RC,Hinton DR,Incardonna F,et al.Extensive peroxynitrite activity during progressive stages of central nervous system inflammation.J Neuroimmunol,1997,77:1-7.
  • 3Rentzos M,Nikolaou C,Anagnostouli M,et al.Serum uric acid and multiple sclerosis.Clin Neurol Neurosurg,2006,108:527-531.
  • 4Wingerchuk DM,Lennon VA,Pittock SJ,et al.Revised diagnostic criteria for neuromyelitis optica.Neurology,2006,66:1485-1489.
  • 5Polman CH,Reingold SC,Edan G,et al.Diagnostic criteria for multiple sclerosis:2005 revisions to the "McDonald Criteria".Ann Neurol,2005,58:840-846.
  • 6Vladimirova O,O'Connor J,Cahill A,et al.Oxidative damage to DNA in plaques of MS brains.Mult Scler,1998,4:413-418.
  • 7Hooper DC,Bagasra O,Marini JC,et al.Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite:implications for the treatment of multiple sclerosis.Proc Natl Acad Sci U S A,1997,94:2528-2533.
  • 8Toncev G,Milicic B,Toncev S,et al.Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction.Eur J Neurol,2002,9:221-226.
  • 9Peng F,Zhang B,Zhong X,et al.Serum uric acid levels of patients with multiple sclerosis and other neurological diseases.Mult Scler,2008,14:188-196.
  • 10Constantinescu CS,Freitag P,Kappos L.Increase in serum levels of uric acid,an endogenous antioxidant,under treatment with glatiramer acetate for multiple sclerosis.Mult Scler,2000,6:378-381.

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