前列腺癌骨转移危险因素分析-单中心235例病例对照研究

Analysis of risk factors of bone metastases from prostate cancer-single center 235 case control study

目的初步探讨前列腺癌骨转移的危险因素。方法以SPECT全身骨显像为诊断前列腺癌骨转移的金标准,采用单中心对照研究的方法分析235例前列腺癌患者的年龄、Gleson评分、血清前列腺特异性抗原(TPSA)、血清游离前列腺特异性抗原(FPSA)及血清F/T值与前列腺癌骨转移的相关性。结果235例前列腺癌患者中101例发生骨转移,134例未发生骨转移,单因素分析显示年龄、Gleason评分、TPSA、FPSA、F/T值与前列腺癌骨转移密切相关(P<0.05),多因素Logistic回归分析显示:年龄(OR=1.08,P<0.05)、Gleason评分(OR=2.90,P<0.05)、TPSA值(OR=1.05,P<0.05)是其主要的独立危险因素。分层研究显示;在年龄≥70岁、Gleason评分≥7分、TPSA>20ng/ml组中骨转移的患者明显多于其他组,差异均具有统计学意义(P<0.05)。结论年龄、Gleason评分及TPSA是前列腺癌骨转移的主要危险因素,年龄≥70岁、Gleason评分≥7分、TPSA>20ng/mL时将增加患者骨转移的风险。

Objective To explore the risk factors of bone metastasis of prostate cancer.Methods On SPECT bone scan is the gold standard for the diagnosis of prostate carcinoma with bone metastasis.By using the method of comparative study of single center we analyzed 235 prostate cancer patients Age,Gleson score,Serum prostate specific antigen,Serumfree prostate specific antigen and Serum F/T level which is correlation with bone metastasis of prostate cancer.Results 235 cases of prostate cancer patients with bone metastasis occurred in 101 cases and 134 cases did not have bone metastasis.By univariate analysis,bone metastasis of prostate cancer was correlated with age,Gleason score,TPSA,FPSA,F/T（P〈0.05）.Multivariate Logistic regression analysis showed that age（OR = 1.08）,Gleason score（OR = 2.90）,TPSA（OR = 1.05） are the independent risk factors and Stratification study shows ≥70 years,Gleason score ≥7 score,TPSA〉 20 ng/mL group of bone metastasis in patients with significantly more than the other groups,there were significant differences（P〈0.05）.Conclusion Age,Gleason score and TPSA are risk factors of patients with bone metastasis of prostate cancer in our center and ≥70 years,Gleason score ≥7 score,TPSA 〉20 ng/mL will increase the risk of patients with bone metastasis.