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典型胫前黏液性水肿患者2例及文献复习

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摘要 胫前黏液性水肿(pretibial myxedema,PM)是Graves病的甲状腺外的特殊表现,临床上较少见,与血清甲状腺激素水平无关。发病病因和机制与GO相类似。目前尚无公认有效的标准治疗方法,需要根据患者个体具体情况选择治疗方案。就PM的发病机制,针对免疫级联反应的靶向治疗有望成为新的研究方向。
出处 《西南国防医药》 CAS 2015年第5期572-574,共3页 Medical Journal of National Defending Forces in Southwest China
关键词 胫前黏液 水肿
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参考文献15

  • 1Missner SC, Ramsay EW, Houck HE, et al. Graves" s disease presenting as localized myxedema in a thigh donor graft site[J]. J Am Acad Dermatol, 1998, 39: 846-849.
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  • 3Omohundro C, Dijkstra J, Camisa C, et al. Early onset pretibial myxedema in the abscence of ophthalmopathy: a morphologic evolution[J]. Cutis, 1996, 58: 211-214.
  • 4Georgala S, Katoulis AC, Georgala C, et al. Pretibial myxedema as the initial manifestation of Graves" disease [J]. J Eur Acad Dermatol Venereol, 2002, 16: 380-383.
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  • 6Smith TJ, Hoa N. Immunoglobulins from patients with Graves" disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like gTowth factor- I receptor [J]. J Clin Endocrinol Metab, 2004, 89: 5076.
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二级参考文献3

  • 1黎明,潘慧清.胫前粘液性水肿1例[J].岭南皮肤性病科杂志,2004,11(3):279-280. 被引量:2
  • 2[1]陈灏珠主编.实用内科学.第11版,北京:人民卫生出版社,2002:916-919.
  • 3[4]Daumerie C,Ludgate M,Costagliola S,et al.Evidence for thyrotropin receptor immunoreactiveity in pretibial connective tissue from patients With thyroid-associated dermopathy.Eur J Endocrinol,2002,146(1):35~38.

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