染色体9p21上rs2383207位点的单核苷酸多态性分布与冠心病的相关性
摘要
WTCCC(the Wellcome Trust Case Control Consortium)等发现人类9号染色体上的9p21.3区域上的基因和冠心病发病显著相关。为探讨与中国浙江汉族人群冠心病的相关性,本文对354例冠状动脉造影检查患者进行了9p21区域多态位点rs2383207上的基因进行多态性测定,以探讨其是否与中国浙江汉族人群中的冠心病发病相关。现报告如下。
出处
《中国药物与临床》
CAS
2015年第5期623-624,共2页
Chinese Remedies & Clinics
基金
浙江省温州市科技局基金(Y20110145)
参考文献11
-
1The Wellcome Trust Case Control Consortium.Genome-wide association study of 14,000 cases of seven common diseases and3,000 shared controls[J].Nature,2007,447(7145):661-678.
-
2Lanktree MB,Hegele RA.Gene-gene and gene-environment interactions:new insights into the prevention,detection and management of coronary artery disease[J].Genome Med,2009,26(2):28.
-
3Schunkert H,Gotz A,Braund P,et al.Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease[J].Circulation,2008,117(13):1675-1684.
-
4Hinohara K,Nakajima T,Takahashi M,et al.Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations[J].J Hum Genet,2008,53(4):357-359.
-
5Palomaki GE,Melillo S,Bradley LA.Association between 9p21genomic markers and heart disease:a meta-analysis[J].JAMA,2010,303(7):648-656.
-
6Cunnington MS,Keavney B.Genetic mechanisms mediating atherosclerosis susceptibility at the chromosome 9p21 locus[J].Curr Atheroscler Rep,2011,13(3):193-201.
-
7Musunuru K.Regulatory elements in noncoding DNA in the chro-mosome 9p21 locus[J].Circ Cardiovasc Genet,2011,4(3):330-331.
-
8Helgadottir A,Thorleifsson G,Manolescu A,et al.A common variant on chromosome 9p21 affects the risk of myocardial infarction[J].Science,2007,316(5830):1491-1493.
-
9Shen GQ,Rao S,Martinelli N,et al.Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population[J].J Hum Genet,2008,53(2):144-150.
-
10Shen GQ,Li L,Rao S,et al.Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease[J].Arterioscler Thromb Vasc Biol,2008,28(2):360-365.
-
1罗元平,郑志超,庞国良.低渗溶血法清除涂片中红细胞的应用[J].吉林医学,1995,16(6):354-354. 被引量:2
-
2张琦,钟光珍,陈兴栋,王笑峰,杨新春.染色体9p21上rs10757278单核苷酸多态性与汉族人心肌梗死的相关性分析[J].中国煤炭工业医学杂志,2010,13(2):173-174. 被引量:1
-
3金晓东,傅广成,许先国,朱发明,严力行.中国浙江义乌人群RhD真阴性和RhDel表型的分子机制研究[J].中国实验血液学杂志,2010,18(4):1051-1054. 被引量:5
-
4谢伟贤,黄泽棋,王晓娟,韩慧明.溶血对时间分辨免疫荧光分析法测定胰岛素的影响[J].检验医学与临床,2014,11(4):443-444. 被引量:3
-
5彭哲华.溶血对时间分辨免疫荧光分析法测定胰岛素的影响[J].中国实用医药,2015,10(17):72-74.
-
6蔡俊明,李涛,张国良,李松,赵菲,许香广.冠心病外周血单核细胞肺炎衣原体病原体检测的意义[J].医学理论与实践,2005,18(8):878-880.
-
7白燕妮.1例多发性骨髓瘤病人血型变异的临床分析与护理[J].护理研究(上旬版),2012,26(5):1244-1244.
-
8李涛,张国良,许香广,张允奇,黄建平,李松,方卫华.冠心病外周血单核细胞肺炎衣原体包涵体的检测[J].中国医师杂志,2005,7(11):1554-1555.
-
9王慧君,Bi Weimin,吴冰冰,周文浩,Cheung Sau W.染色体基因芯片分析在临床遗传病诊断中的应用和结果解读[J].中国循证儿科杂志,2014,9(3):227-235. 被引量:7
-
10卢乐磊,唐启彬,邹声泉.染色体9P21区段抑癌基因簇在转录及翻译水平的异常与胆管癌生物及临床特点的关系[J].健康大视野(医学版),2005,13(12):7-9.