摘要
本文介绍了血脑屏障的结构、功能及该部位的转运蛋白(ATP结合盒转运蛋白和溶质载体转运蛋白),以及它们在血脑屏障转运过程中的作用。通过脑微血管内皮细胞模型和在体脑微透析技术,定性定量地探讨了转运蛋白在中药有效成分跨血脑屏障中的作用。
This article briefly presented the structure and function of the blood brain barrier(BBB) and the transporter proteins at this site,including ATP binding cassette transporter protein,solute carrier transporter proteins and their role in the transport process of BBB. And the article also summarized the qualitative and quantitative evaluations of drug transport across the BBB,mainly through the model of brain microvascular endothelial cells in vitro and brain mierodialysis techniques in vivo and their application to the study of Chinese materia mediea. The function of transporter proteins in the transport of active corn ponents of Chinese materia medica across the BBB was also discussed.
出处
《药学服务与研究》
CAS
2015年第2期81-87,共7页
Pharmaceutical Care and Research
基金
国家自然科学基金(81173020
81373376)
关键词
血脑屏障
ATP结合盒
溶质载体
转运蛋白
中药
blood brain barrier
ATP-binding cassette
solute carrier
transporter proteins
Chinese materia medica