CPAP治疗OSAHS伴动脉粥样硬化患者对动脉粥样硬化的稳定作用

CPAP for the Treatment of OSAHS with Stable Effect on Atherosclerosis in Patients with Atherosclerosis

目的探讨持续气道正压通气(CPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴动脉粥样硬化患者对动脉粥样硬化的稳定作用。方法 OSAHS患者64例行无创正压呼吸机治疗3个月,检测治疗前、后多导睡眠监测、白细胞介素-6(IL-6)、C反应蛋白水平(CRP)及颈动脉内膜中层厚度(IMT)。结果呼吸机治疗后白细胞介素-6、C反应蛋白水平、颈动脉内膜中层厚度及呼吸暂停指数(AHI)均下降,与治疗前比较差异有统计学意义(P<0.05);最低血氧饱和度(Sp O2)较治疗前升高(P<0.05)。结论 CPAP治疗可能通过降低OSAHS患者血清CRP水平、IL-6,抑制OSAHS患者炎性反应,因而降低OSAHS患者动脉粥样硬化的进程以及心脑血管疾病的发生率。

Objective To investigate continuous positive airway pressure （CPAP） in treatment of obstructive sleep apnea hypopnea syndrome associated with atherosclerosis in patients with stable effect on atherosclerosis. Methods OSAHS in 64 patients with noninvasive positive pressure ventilation in the treatment of 3 months, detected before and after treatment, polysomnography, interleuldn-6 （IL-6）, C reactive protein （CRP） and carotid artery intima-media thickness （IMT）. Result After ventilator treatment interleukin-6, C-reactive protein levels, carotid intima-media thickness and apnea hypopnea index （AHI） were decreased, compared with that before treatment （P〈0.05） statistical significance; the lowest oxygen saturation （SpO2） compared with those before treatment （P〈0.05） increased. Conclusion CPAP treatment could decrease the level of serum CRP in patients with OSAHS, IL-6, inhibit inflammatory reaction in patients with OSAHS, and thus reduce the incidence of atherosclerosis in patients with OSAHS process and cardiovascular and cerebrovascular diseases.