摘要
采用Themo BDS HYPERSIL C18色谱柱（100 mm×4.6 mm×2.4μm）,以乙腈-水（35∶65,体积比）为流动相,流速1.0 mL/min,检测波长228 nm,柱温40℃,进样量5μL,在前述条件下建立了测定化妆品中双酚A的高效液相色谱方法.结果发现,在0）.05140～2.056μg/mL范围内,双酚A峰面积与其质量浓度呈良好线性关系（r=0.9999）;低浓度水平下的平均加标回收率为98.9％～100.8％（相对标准偏差＜2％）,高浓度水平下的平均加标回收率为100.6％～102.7％（相对标准偏差＜3％）;检出限为0.015μg/mL,检出质量比为0.3μg/g.所建立的方法操作简便快捷,结果准确可靠,可用于化妆品中双酚A的测定.
To establish a high performance liquid chromatographic method for determination of bisphenol A in cosmetics,a Themo BDS HYPERSIL C18 column（100 mm × 4.6 mm× 2.4 μm） was used.The mobile phase was acetonitrile-water（35/65,volume ratio）,the flow rate was 1.0 mL/min,the detection wavelength was 228 nm,the column temperature was 40℃.The results showed that the linear response range was 0.05140 to 2.056 μg/mL for bisphenol A （r =0.9999）.The average recoveries were 98.9％ to 100.8％（RSD＜2％） for lower concentration level and 100.6％ to 102.7％ （RSD＜3％） for higher concentration level.Limit of detection was 0.015 μg/mL and corresponding mass ratio was 0.3 μg/g.This method is simple and fast with accurate and reliable results,which can be used to determine bisphenol A in cosmetics.
出处
《香料香精化妆品》
CAS
2015年第2期37-39,42,共4页
Flavour Fragrance Cosmetics
