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雌激素受体在妇科恶性肿瘤中的作用 被引量：4

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摘要 雌激素或雌激素样物质通过与雌激素受体（ER）如ERd、ERβ或G蛋白偶联膜受体（GPR30）结合而发挥生物学效应,促进机体健康发育,尤其是调节女性生殖系统的功能.目标组织或细胞中的雌激素受体类型的表达量与妇科恶性肿瘤疾病发展转归密切相关.妇科恶性肿瘤严重影响女性健康,极大危害女性生命,因此深入研究雌激素受体的表达变化,将对肿瘤药物的临床应用起一定的指导作用.
作者 陈梦 赵丕文 孙丽萍 臧金凤 王婧瑶
机构地区 北京中医药大学基础医学院教学实验中心
出处 《中国医药》 2015年第6期926-928,共3页 China Medicine
基金 北京中医药大学自主课题（2014-SYJS-02）
关键词 乳腺肿瘤 子宫内膜肿瘤 卵巢肿瘤 雌激素受体
分类号 R737 [医药卫生—肿瘤]
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参考文献32

  • 1Green S, Walter P, Kumar V, et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A [ J]. Na- ture, 1986,320 (6058) : 134-139.
  • 2Greene GL, Gilna P, Waterfield M, et al. Sequence and expres- sion of human estrogen receptor complementary DNA[ J]. Science, 1986,231 (4742) :1150-1154.
  • 3Kuiper GG, Enmark E, Peho-Huikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary [ J 1. Proc NatI Acad Sci U S A, 1996,93(12) :5925-5930.
  • 4Bord S, Homer A, Beavan S, et al. Estrogen receptors alpha and beta are differentially expressed in developing human bone [ J ]. J Clin Endocrinol Metab, 2001,86(5) :2309-2314.
  • 5Carmeci C, Thompson DA, Ring HZ, et al. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer [ J ]. Genomics, 1997,45(3) :607-617.
  • 6Revankar CM, Cimino DF, Sklar LA, et al. A transmembrane intraeellular estrogen receptor mediates rapid cell signaling [ J ]. Science, 2005,307 ( 5715 ) : 1625-1630.
  • 7Filardo E J, Graeber CT, Quinn JA, et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinieopathologic determinants of tumor progression [ J ]. Clin Cancer Res, 2006, 12 ( 21 ) : 6359-6366.
  • 8Prnssnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30 [ J ]. Mol Cell Endocrinol, 2009,308 (1-2) :32-38.
  • 9Jensen EV, Block GE, Smith S, et al. Estrogen receptors and breast cancer response to adrenaleetomy [ J ]. Natl Cancer Inst Monogr, 1971,34:55-70.
  • 10Saha Roy S, Vadlamudi RK. Role of estrogen receptor signaling in breast cancer metastasis[J] Int J Breast Cancer, 2012,2012 : 654-698.

二级参考文献49

  • 1韩晶,王培军,汤如勇,方建萍.雌激素受体亚型在不同乳腺组织中的表达及其与乳腺癌关系的研究[J].同济大学学报（医学版）,2005,26(5):21-24. 被引量：17
  • 2Guillermo N, Lingegowda S. Estrogen cycle modulates ovarian carcinoma growth. Clin Cancer Res 2009; 15(9): 2971-2977.
  • 3Maggiolini M, Picard D. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 2010; 204: 105-114.
  • 4Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel R. Identification of a gene (GPR30) with homology to the Gprotein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 1997; 45: 607-617.
  • 5Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Enel J Med 2006: 354: 270-282.
  • 6Wang C, Prossnitz ER, Roy SK. G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology 2008; 149(9): 4452-4461.
  • 7He YY, Cai B, Yang YX, Liu XL, Wan XP. Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ ERK mitogen-activated protein kinase pathway. Cancer Sci 2009; 100(6): 1051-1061.
  • 8Lazari MF, Lucas TF, Yasuhara F, Gomes GR, Siu ER, Royer C, Femandes SA, Porto CS. Estrogen receptors and function in the male reproductive system. Arq Bras Endocrinol Metab 2009; 53(8): 923-933.
  • 9Smith HO, Leslie KK, Singh M, Qualls CR, Revankar CM, Joste NE. GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol 2007; 196(386): 9-11.
  • 10Chen H (陈虹). The research progress of a novel estrogen receptor GPR30. J Endoc Surg (内分泌外科杂志) 2008; 2 (2): 131-133 (Chinese, English abstract).

共引文献39

同被引文献46

  • 1付国勤,余丽侠.围绝经期综合征病因及防治对策[J].中国基层医药,2006,13(2):346-347. 被引量：2
  • 2韩文全,李艳芹,何志松.黄豆苷元的研究与开发[J].食品与药品,2006,8(05A):73-74. 被引量：4
  • 3王艳梅,吕立勋.黄豆苷元的药理作用及临床应用[J].中国药师,2007,10(9):910-912. 被引量：27
  • 4Yu KD, Di GH, Wu J, et al. Development and trends of surgical modalities for breast cancer in China: a review of 16-year data[ J]. Ann Surg Oncol, 2007, 14 ( 9 ) : 2502-2509. DOI: 10. 1245/ s10434-007 -9436-2.
  • 5Blarney RW, Hornmark-Stenstam B, Ball G, et al. ONCOPOOL - a European database for 16,944 cases of breast cancer[ J]. Eur J Cancer, 2010,46 ( 1 ) : 56-71. DOI: 10. 1016/j. ejea. 2009. 09. 009.
  • 6Allred DC, Harvey JM, Berardo M, et al. Prognostic and predic- tire factors in breast cancer by analysis [ J ] Mod Pathol, 1998,1 1 (2) : 155-168.
  • 7Harvey JM, Clark GM, Osborne CK, et al. Estrogen receptor sta- tus by immunohistochemistry is superior to the ligand-blnding assay for predicting response to adjuvant endocrine therapy in breast cancer[J]. J CIin Oncal, 1999,17(5) :1474-1481.
  • 8Hammond ME, Hayes DF, Wolff AC, et al. American society of clinical oncology/eollege of american pathologists guideline recom- mendations for immunohistochemical testing of estrogen and progesterone receptors in breast eaneer[ J]. J Oncol Pract, 2010,6(4) :195-197. DOI: 10. 1043/1543-2165-134.7. e48.
  • 9Simmons C, Miller N, Geddie W, et al. Does confirmatoly tumor biopsy alter the management of breast cancer patients with distant metastases [J]. Ann Oncol, 2009,20(9) :1499-1504. DOI: 10. 1093/annonc/mdp028.
  • 10Amir E, Clemons M, Purdie CA, et al. Tissue confirmation of disease recmxence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies [ J]. Cancer Treat Rev, 2012,38(6) :708-714. DOI: 10.1016/j. ctrv. 2011. 11. 006.

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中国医药
2015年 第6期

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