泰山蛹虫草多糖对免疫抑制小鼠血清蛋白含量和体内抗氧化能力的影响

Effect of Cordyceps taishanensis polysaccharide on protein content in serum and antioxidant activity in immunosuppressive mice

目的:研究泰山蛹虫草多糖(Cordyceps taishanensis polysaccharide,CTP)对免疫抑制小鼠血清蛋白含量和抗氧化能力的影响。方法:通过对小鼠灌服多糖实验,观察CTP对小鼠血清总蛋白、白蛋白及球蛋白含量和抗氧化能力的影响。结果:与环磷酰胺(Cyclophosphamide,CY)模型组比较,三个CTP组的血清总蛋白、球蛋白和白蛋白含量均极显著增高(p<0.01);三个CTP组的红细胞SOD活性和血清CAT活性均显著提高(p<0.01或p<0.05),红细胞MDA含量均极显著减少(p<0.01)。结论:CTP能显著提高CY所致的免疫损伤小鼠的血清蛋白含量,在一定程度上CTP能减轻CY对小鼠肝脏的损害作用;CTP也能改善CY所致免疫损伤小鼠的抗氧化能力。

Objective: To study the effects of Cordyceps taishanensis polysaccharide (CTP)on protein content in serum and antioxidant activity in immunosuppressive mice. Methods.. Through gavage experiments in mice, the effects of CTP on the amount of total proteins ( TP), albumin (ALB) and globulin (GLO) in serum and antioxidant activity were analyzed.Results:Compared with the CY model group,the amount of TP,ALB and GLO in serum were increased significantly(p <0.01 ) ,the activities of superoxide dismutase(SOD)in erythrocytes and catalase(CAT) in serum were significantly increased ( p < 0.05 or p < 0.01 ) and the content of malondialdehyde (MDA) in erythrocytes were decreased significantly ( p < 0.01 ) in the three CTP treatment groups. Conclusion.. CTP could significantly increase protein content in serum and reduce the damage at some level to liver function of immunosuppressive mice induced by CY. CTP could also improve antioxidant activity of CY- induced immunosuppressive mice to a certain extent.