普奈洛尔凝胶外涂治疗婴幼儿血管瘤的临床疗效与安全性研究

The Clinical Efficacy and Safety of Infantile Hemangioma with Propranolol Gel

目的探讨普奈洛尔凝胶外涂治疗婴幼儿血管瘤的临床疗效与安全性。方法将我院于2013年1月至2014年1月收治的55例婴幼儿血管瘤患者作为研究对象,并采用普萘洛尔凝胶外涂的方式进行治疗,观察比较对于不同类型血管瘤的临床疗效以及治疗前后的血流峰值和阻力系数,同时记录患儿的不良反应等情况。结果治疗后经Achauer评定疗效,Ⅰ级患儿为7例(12.7%)、Ⅱ级患儿为15例(27.3%)、Ⅲ级患儿为25例(45.5%)、Ⅳ级患儿为8例(14.5%),其中对于浅表型血管瘤疗效优于混合型以及深部型(P<0.05);同时血管瘤血流峰值较治疗前显著降低,而阻力系数较治疗前显著增高(P<0.05)。结论采用普萘洛尔凝胶外涂的方法对于浅表型血管瘤患儿临床疗效显著,安全无副作用,值得进行临床推广。

Objective To investigate the clinical efficacy and safety of Infantile hemangioma with prop- ranolol gel. Methods 64 cases of infantile hemangioma In our hospital from 2013 January to 2014 January were having propranolol gel, peak flow, resistance coefficient and different types of clinical curative effect of hemangi- oma were obversed and compared, at the same time patients with adverse reactions was recorded. Results After the treatment,The results were evaluated by using Achauer system, scale Ⅰ , Ⅱ , Ⅲ, Ⅳ were 7 （ 12.7% ） , 15 （27.3%） ,25 （45.5%）, and 8 （14.5%）, wherein the superficial hemangiomas curative effect was better than the mixed type and deep type （P 〈 0.05 ）. At the same timethe hemangioma peak flow was decreased, and the resistance was increased significantly （ P 〈 0.05 ）. Conclusion The treatment of using propranolol gel coated for infantile hemangioma have a curative effecty and no side effects, it is worthy of clinical promotion.