慢乙肝中度患者的FT_4、TT_4与TBA和ADA的关系

Relationships Between FT_4 and TT_4 with TBA and ADA in Patients with Moderate Chronic Hepatitis B

目的探讨慢乙肝中度患者的FT4、TT4与TBA和ADA的关系。方法收集在本院2014年下半年住院的慢乙肝轻度患者30例、中度患者34例、重度患者30例和正常体检者30例,检测血清的FT4、TT4、TBA和ADA,并进行统计分析。结果慢乙肝中度患者的FT4、TT4、ADA和TBA水平均高于慢乙肝轻度患者和正常对照组,差异显著均有统计学意义(P=0.000)。慢乙肝中度患者的FT4与ADA、TBA呈正相关(r=0.412,0.362;P=0.016,0.035),TT4与TBA呈正相关(r=0.387,P=0.024),与ADA无相关性(r=0.124,P=0.486)。结论 FT4、TT4、TBA和ADA在评价慢乙肝中度患者的肝功能损害有重要的临床意义。

Objective To explore the relationships between FT4 and TT4 with TBA and ADA in patients with moderate chronic hepatitis B. Methods The serum levels of FT4, TT4, TBA and ADA in 30 patients with mild chronic hepatitis B, 34 patients with moderate chronic hepatitis B, 30 patients with severe chronic hepatitis B and 30 cases of healthy controls were detected and results were statistically analyzed. Results The serum levels of FT4, TT4, TBA and ADA in patients with moderate chronic hepatitis B were higher than that of patients with mild chronic hepatitis B and health controls （ P 〈 0. 001 ）. The FT4 levels in patients with moderate chronic hepatitis B was positively correlated with ADA and TBA levels （r = 0. 412, 0. 412 ; P = 0. 016, 0.035）. The TT4 level was positively related with TBA level （ r = 0. 387, P = 0. 387 ） , and no correlation with ADA （ r = 0. 124, P = 0. 124 ）. Conclusion The serum levels of FT4, TF4, TBA and ADA have important clinical significance in the evaluation of liver dysfunction in patients with moderate chronic hepatitis B.