老年高血压伴2型糖尿病患者血压变异性及其与认知功能的关系

Elderly Patients with Hypertension and Blood Pressure Variability in Patients with Type 2 Diabetes Mellitus and Its Relationship with Cognitive Function

目的:探讨老年高血压伴2型糖尿病患者血压变异性及其与认知功能的关系。方法:采用回顾性方法,选取2011年3月-2014年11月收治的120例老年患者的临床资料,将其分为两组,单纯高血压患者为对照组,老年高血压合并2型糖尿病患者为观察组,每组各60例。对两组患者的一般情况、认知功能以及24 h动态血压(24 h ABPM)变化情况进行观察比较。结果:观察组患者24 h收缩压标准差、24 h收缩压变异系数、白天收缩压标准差、白天收缩压变异系数、夜间收缩压标准差和夜间收缩压变异系数均明显高于对照组,差异均有统计学意义(P<0.05);而其余的24 h动态血压指标与对照组比较差异无统计学意义(P>0.05);观察组患者认知能力明显优于对照组,差异有统计学意义(P<0.05)。结论:老年高血压合并糖尿病患者血压变异性增加,而且其增加与认知功能减退有着密切的关系。

Objective：To explore the relationship of elderly patients with hypertension and blood pressure variability in patients with type 2 diabetes and cognitive function. Method：A retrospective analysis was performed on clinical data of 120 elderly patients from March 2011 to November 2014,and were divided into two groups. Hypertensive patients were control group only,elderly hypertensive patients with type 2 diabetes mellitus patients were the observation group,with 60 cases in each group. Two groups of patients in general,cognitive ability and the 24 hours ambulatory blood pressure（24 h ABPM）changes were observed and compared.Result：The observation group of patients with 24 h systolic blood pressure standard deviation,24 h systolic blood pressure variation coefficient,systolic blood pressure standard deviation during the day,during the systolic blood pressure variation coefficient,nocturnal systolic blood pressure standard deviation and nighttime systolic blood pressure variation coefficient were higher than the control group patients, statistically significant difference（P〈0.05）. While the rest of the 24 hours ambulatory blood pressure index compared with the control group had no obvious difference,no statistical significance（P〉0.05）.The observation group of patients with cognitive ability was better than control group,the difference is statistically significant（P〈0.05）.Conclusion：The blood pressure variability in elderly hypertensive patients with diabetes increased,and there is a close relationship between the increase of loss and cognitive function.