脑梗死TOAST分型与同型半胱氨酸和血尿酸水平关系的研究

Study on the Relationship between TOAST Subtypes of Cerebral Infarction and the Concentration of Homocysteine and Uric Acid

目的:探讨不同TOAST分型的脑梗死与同型半胱氨酸(Hcy)、血尿酸(UA)水平之间的关系。方法:选取本院急性脑梗死患者121例,按TOAST分型方法进行分型,另选取50例同期门诊健康体检者为对照组,测定每组患者Hcy、UA水平并进行对比。结果:(1)脑梗死组Hcy、UA水平均高于对照组(P<0.01);(2)Hcy水平对比为:LAA型高于其他4个亚型及对照组(P<0.01),SAA型高于SOE型(P<0.05),其余亚型两两对比无差异(P>0.05);CE型、SAA型、SUE型高于对照组(P<0.05),SOE型与对照组比较无差异(P>0.05);(3)UA水平对比为:LAA型高于CE型、SAA型、SUE型及对照组(P<0.05),SAA型高于对照组(P<0.01),CE型、SOE型、SUE型与对照组比较无差异(P>0.05)。结论:Hcy、UA水平与脑梗死发病密切相关,其中对于LAA亚型脑梗死患者发病有更为重要的临床意义。

Objective：To investigate the relationship between TOAST subtype of cerebral infarction and the concentration of homocysteine（Hcy）and blood uric acid（UA）. Method：Data was collected prospectively from 121 acute cerebral infarction patients in our hospital,and all the patients were classified into different subtypes according to TOAST criteria. In addition,50 healthy people made physical examination at the same term were selected as the control group. The concentration of Hcy and UA of each group were tested respectively for comparison. Result：（1）Cerebral infarction patients group had higher concentration of Hcy and UA than the control group（P〈0.01）;（2）Comparison of Hcy concentration：LAA subtype was higher than the other 4 subtype groups and the control group（P〈0.01）,SAA subtype was higher than SOE subtype（P〈0.05）,the left two groups had same Hcy concentration（P〉0.05）;CE,SAA and SUE subtype groups were all higher than the control group（P〈0.05）,and SOE subtype group was almost the same with the control group（P〉0.05）;（3）Comparison of UA concentration：LAA subtype was higher than CE,SAA,SUE subtype groups and the control group（P〈0.05）,SAA subtype group was higher than the control group（P〈0.01）,and CE, SOE and SUE subtype groups were almost the same with the control group（P〉0.05）. Conclusion：The concentration of Hcy and UA is closely related to the morbidity of cerebral infarction,which also has more clinical significance to patients with cerebral infarction of LAA subtype.