2Smemenza GL. Targeting HIF-1 for cancer therapy [J]. Nat Rev Cancer, 2003, 3:721-727.
3Semenza GL, Jiang BH, Leung SW, et al. Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxiainducible Factor 1[J]. J Biol Chem,1996, 271(51) :32529-32537.
4Chiarugi V, Magnelli L, Chiarugi A, et al. Hypoxia induces pivotal tumor angiogenesis control factors including P53, vascular endothelial growth factor and the NFkappaB - dependent inducible nitric oxide synthase and cyclooxygenase- 2[J]. J Cancer Res Clin Oncon, 1999, 125 (8- 9) : 5252-5281.
5Goldberg MA, Schneider TJ. Similarities between the Oxygen-sensing Mechanisms Regulating the Expression of Vascular Endothelial Growth Factor and Erythropoie-tin[J]. J Biol Chem,1994, 269: 4355- 4359.
6Kourembanas S, Marsden PA, McQuillan LP, et al. Hypoxia Induces Endothelin Gene Expression and Secretion in Cultured Human Endothelium[J]. J Clin Invest, 1991, 88 : 1054-1057.
8Maltepe E. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta[J]. J Development,2005,132( 15):3393-3403.
9Lee YM. Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development[J]. J Dev Dyn, 2001, 220(2): 175-186.
10Ramirez-Bergeron DL. Hypoxia affects mesoderm and enhances hemangioblast specification during early development[J]. J Development, 2004,131 ( 18):4623 -4634.
