期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

印记基因在胎盘相关性疾病中的作用 被引量：1

原文传递
导出
摘要 基因印记是指通过DNA甲基化、组蛋白修饰等方式使不同亲本来源的等位基因带上亲本特异的标志，其中带有印记的等位基因失活，而非印记等位基因表达，具有这种特征的基因被称为印记基因。父源性等位基因沉默者称为父源性印记基因，母源性等位基因沉默者称为母源性印记基因[1]。目前在小鼠中发现的印记基因有130多个，人类有70余个[2]。
作者 郭秀荣 冯晨霞 王谢桐
机构地区 山东省汶上县人民医院妇产科 山东大学附属省立医院产科
出处 《中华围产医学杂志》 CAS CSCD 2015年第4期315-317,共3页 Chinese Journal of Perinatal Medicine
关键词 印记基因 相关性疾病 胎盘 DNA甲基化 基因沉默 组蛋白修饰 基因印记 等位基因
分类号 R714.5 [医药卫生—妇产科学]
  • 相关文献

参考文献34

  • 1Peters J. The role of genomic imprinting in biology and disease: an expanding view[J]. Nat Rev Genet, 2014, 15(8): 517-530.
  • 2Tunster S J, Jensen AB, John RM. Imprinted genes in mouse placental development and the regulation of fetal energy stores[J]. Reproduction, 2013, 145(5): R117-137.
  • 3Fowden AL, Coan PM, Angiolini E, et al. Imprinted genes and the epigenetic regulation of placental phenotype[J]. Prog Biophys Mol Biol, 2011, 106(1): 281-288.
  • 4Ono R, Nakamura K, Inoue K,et al. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality[J]. Nat genet, 2006, 38(1): 101-106.
  • 5Angiolini E, Fowden A, Coan P, et al. Regulation of placental efficiency for nutrient transport by imprinted genes[J]. Placenta,2006,27:S98- 102.
  • 6Salas M, John R, Saxena A,et al.Placental growth retardation due to loss of imprinting of Phlda2[J]. Mech Dev, 2004, 121(10): 1199-1210.
  • 7Pozharny Y, Lambertini L, Ma Y, et al. Genomic loss of imprinting in first-trimester human placenta[J]. Am J Obstet Gynecol, 2010, 202(4): 391.e1- 391.e8.
  • 8Yu L, Chen M, Zhao D, et al. The H19 gene imprinting in normal pregnancy and pre-eclampsia[J]. Placenta, 2009, 30(5): 443-447.
  • 9van Dijk M, Mulders J, Kenst A, et al. Differential downregulation of alphaT-catenin expression in placenta: trophoblast cell type dependent imprinting of the CTNNA3 gene[J]. Gene Expr Patterns, 2004, 5(1): 61-65.
  • 10Fowden AL, Constancia M. Maternal-fetal resource allocation[J]. Placenta, 2012, 33 Suppl 2: e1-2.

二级参考文献14

  • 1Angiolini E, Fowden A, Coan P, et al. Regulation of placental efficiency for nutrient transport by imprinted genes. Placenta, 2006, 27(Suppl A) :s98-s102.
  • 2Constancia M, Hemberger M, Hughes J, et al. Placental specific IGF-Ⅱ is a major modulator of placental and fetal growth. Nature, 2002, 417:945-948.
  • 3Vambergue A, Fajardy I, Dufour P, et al. No loss of genomic imprinting of IGFⅡ and H19 in placentas of diabetic pregnancies with fetal macrosomia. Growth Horm IGF Res,2007,17: 130-136.
  • 4Isles AR, Holland AJ. Imprinted genes and mother-offspring interactions. Early Hum Dev, 2005, 81:73-77.
  • 5Constancia M, Kelsey G, Reik W. Resourceful imprinting. Nature, 2004, 432:53-57.
  • 6Antonazzo P, Alvino G, Cozzi V, et al. Placental IGF2 expression in normal and intrauterine growth restrieted(IUGR) pregnancies. Placenta, 2008, 29:99-101.
  • 7Jaddoe VW,Wittteman JC.Hypotheses on the fetal origins of adult diseases:contributions of epidemiological studies.Eur J Epidemiol,2006,21:91-102.
  • 8Oken E,Gillman MW.Fetal origins of obesity.Obes Res,2003,11:496-506.
  • 9Kanber D,Buiting K,Zeschnigk M,et al.Low frequency of imprinting defects in ICSI children born small for gestational age.Eur J Hum Genet,2009,17:22-29.
  • 10Riesewijk AM,Hu L,Schulz U,et al.Monoallelic expression of human PEG1 is paralleled by parent-specific methylation in fetuses.Genomics,1997,42,236-244.

同被引文献3

引证文献1

二级引证文献4

中华围产医学杂志
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部