摘要
c-myb是myb类转录因子家族中的一员,参与细胞的增殖与分化.它通过激活靶基因调控基因的特定程序,经一定的通路,进行信号转导,调节蛋白质的功能和表达水平.c-myb通过与Wnt信号通路结合,使Lgr5被启动,促使细胞增殖和分化,而且它可以作为一个新的治疗靶点,为结直肠癌的早期诊断和治疗提供依据.
C-myb is a member of the myb transcription factor family and involved in cell proliferation and differentiation.It activates specific target genes to regulate specific program through certain channel,and it takes signal transduction to regulate function and expression of protein.In this paper,c-myb,by binding to Wnt signaling pathway,makes Lgr5 start to promote cell proliferation and differentiation,and it can serve as a new therapeutic target to provide the basis of early diagnosis and treatment for colorectal cancer.
出处
《肿瘤研究与临床》
CAS
2015年第4期286-288,共3页
Cancer Research and Clinic
基金
内蒙古自治区自然科学基金（2013MS11122）
