甘草治疗肾病研究进展

Review on Glycyrrhizae Radix et Rhizoma Treatment of Kidney Disease

本文综述甘草治疗肾脏病的相关研究。甘草其活性成分存在多种药理作用。甘草是中医处方中应用最为广泛的1种药物,被冠以"众药之王"。甘草味甘,性平,归心、肺、脾、胃经,具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效,常作佐使药入多种中药复方。已经证实甘草有诸多保护性和治疗性作用,如抗氧化、抗炎症、解毒、抗癌、抗组胺、抗菌等。而肾脏病的进展与氧化应激、炎症反应、毒素刺激、药物毒性等相关,因此甘草的这些作用又可用于肾脏病治疗。甘草功效呈多向性,对预防和治疗肾损害存在很大优势,在治疗肾脏病的处方中应给予重视。然而作为中药的甘草同样存在一定的不良反应和禁忌症,临床使用中应按照传统中医的思路和方法进行处方。

The aim of this article was to review the research progress on Glycyrrhizae Radix et Rhizoma in treating kidney disease. Licorice is a widely used Chinese herbal, the active ingredients have various pharmacological effects. Glycyrrhizae Radix et Rhizoma is a Chinese herb, which is most widely used in every prescription of traditional Chinese medicine, and is known as the king of public medicine. The value of Glycyrrhizae Radix et Rhizoma has been recognized by doctors. Glycyrrhizae Radix et Rhizoma goes to heart, lung, spleen, stomach, and has the effects of heat-clearing detoxifying, Buzhong Yiqi, relaxing spasm and relieving pain, antitussive and expectorant activity, reconciling various drugs. Its flavour is Ganping, Various protective and therapeutic effects such as antioxidant, anti-inflammatory, detoxification, anticancer, antihistaminic, and antibacterial effects have been depicted for Glycyrrhizae Radix et Rhizoma. And as for the deterioration of kidney associated with oxidative stress, inflammation, toxins stimulation, drug toxicity and so on, licorice with those effects can be used in the treatment of renal diseases. The efficacy of Glycyrrhizae Radix et Rhizoma is diverse, and there is a big advantage for the prevention and treatment of renal damage, and doctors should pay more attention to the prescription in the treatment of kidney disease. However, as Chinese traditional medicine, licorice has adverse reactions and contraindications, clinical use should be carried out in accordance with the ideas and methods of traditional Chinese medicine prescription.