摘要
目的:制备酮洛芬纳米混悬剂,并对处方及制备工艺进行优化.方法:采用沉淀法与高压均质法相结合的方法制备酮洛芬纳米混悬剂,以粒径及其分布为评价指标,采用单因素考察法优化酮洛芬纳米混悬剂的处方及工艺.结果:通过单因素实验考察后得到的最优处方和工艺制备得到的酮洛芬纳米混悬剂,其粒径为109.6 nm,多分散系数为0.297,平均Zeta电位为-21.1 m V.结论:高压均质法制备的酮洛芬纳米混悬剂处方合理,工艺简单.
Objective To optimize the formulation and preparation technology of ketoprofen nanosuspensions. Method The ketoprofen nanosuspensions were prepared by precipitation and high pressure homogenization method and the optimized formulation was obtained by the single factor test method with particle size and its distribution as evaluating indexs. Result The particle size, polydispersity index and Zeta potential of the prepared ketoprofen nanosuspensions were 109.6 nm ,0. 297,-21.1 mV respectively. Conclusion The precipitation and high pressure homogenization technology employed to prepare ketoprofen nanosuspensions is feasible. This study provided potential for the new dosage form development of ketoprofen.
出处
《辽宁大学学报(自然科学版)》
CAS
2015年第2期169-173,共5页
Journal of Liaoning University:Natural Sciences Edition
基金
辽宁省教育厅科学技术研究项目(L2014006)
辽宁大学"大学生创新创业训练计划"(X201310140052)
关键词
酮洛芬
纳米混悬剂
高压均质法
沉淀法
ketoprofen
nanosuspensions
high pressure homogenization
precipitation