急性非ST段抬高型心肌梗死患者血浆NT-proBNP、超敏CRP与冠脉病变的相关性研究

Correlation Study of the Plasma NT-pro BNP,High Sensitive CRP and Coronary Artery Disease in Patients with Non-ST-segment Elevation Acute Myocardial Infarction

目的:探讨急性非ST段抬高型心肌梗死患者血浆NT-pro BNP、超敏CRP对冠脉病变的影响。方法:选择确诊的非ST段抬高型心肌梗死患者132例。作为非ST段抬高组。同时选择非冠心病患者120例,作为对照组。比较两组患者在入院时一般资料、NT-pro BNP水平;分析NT-pro BNP、超敏CRP水平与冠心病患者冠脉病变的关系。结果:对照组、非ST段抬高组性别、年龄、高血压、血脂异常、糖尿病、尿素氮比较差异无统计学意义(P>0.05);非ST段抬高组NT-pro BNP、超敏CRP水平明显高于对照组(P<0.05);单支病变患者NTpro BNP、超敏CRP水平明显低于双支病变,双支病变患者明显低于三支病变患者(P<0.05)。相关性分析显示,冠心病患者冠脉病变与NTpro BNP、超敏CRP水平呈正相关性(r=0.682、0.821,P=0.000)。NT-pro BNP与超敏CRP水平呈正相关(r=0.914,P=0.05)。结论:NT-pro BN、超敏CRP存在明显的相关性,能较好的反应急性非ST段抬高型心肌梗死患者的炎症状态和心功能情况,对患者的危险度判断和指导临床治疗有着积极作用。

Objective：To investigate the influence of Plasma NT-proBNP,high sensitive CRP on Coronary artery disease in patients with non-ST-segment elevation acute myocardial infarction.Method：132 patients with non-ST-segment elevation acute myocardial infarction were selected as the non-ST-segment elevation group,At the same time,120 patients with Non coronary heart disease were selected as the control group,the general admission information and the level of NT-proBNP in the two groups were compared,the relationship between NT-proBNP levels,high sensitive CRP and coronary heart disease in patients with coronary artery disease were analyzed.Result：There were no significant difference in the gender,age, hypertension,abnormal blood fat,diabetes,urea nitrogen between the control group and the non-ST-segment elevation group（P〉0.05）.NT-proBNPN and high sensitive CRP levels in the non-ST-segment elevation group were significantly higher than the control group,the differences were statistical significance（P〈0.05）.The NT-proBNP,high sensitive CRP levels of single branch lesions patients were significantly lower than the double vessel lesion,the double vessel lesion were significantly lower than three vessel lesion,the differences were statistical significance（P〈0.05）.The analysis of correlation showed that the coronary heart disease in patients with coronary artery disease was positively correlated to NT-proBNP and high sensitive CRP levels（r=0.682,0.821,P=0.000）.NT-proBNP was positively correlated to high sensitive CRP levels（r=0.914,P=0.05）.Conclusion：The NT-proBNP is significantly associated with high sensitive CRP.These are reflected the inflammatory state and heart function in patients with non-ST-segment elevation myocardial infarction.It has positive role in the risk judgment of patients and guide clinical treatment.