2-氨基-1,10-邻菲罗啉的合成工艺研究

Research on Synthesis of 2-Amino-1,10-Phenanthroline

研究了以1,10-邻菲罗啉为原料,经氧化和氯代反应合成2-氯-1,10-邻菲罗啉,再经氨基化反应得到目标产物2-氨基-1,10-邻菲罗啉,化合物结构经核磁共振仪、红外分光光度计和质谱仪确认。结果表明,氯代反应的优化反应条件:投料比为1 g:2 m L,溶剂DMF用量为15 m L,反应时间为8 h;氨基化反应的优化反应条件:投料质量比为1:6,反应温度为180℃、时间为2.0 h。该工艺具有原料易得、工艺简单、环境友好等特点,为2-氨基-1,10-邻菲罗啉的合成提供了一条简便的合成路线。

2-chloro-1,10-phenanthroline was prepared by 1,10-phenanthroline though oxidation and chlorination reaction, then the2-amino-1,10-phenanthroline was obtained via the amination of 2-chloro-1,10-phenanthroline, the 1,10-phenanthroline derivatives were characterized by NMR, IR and MS. Results showed that the optimized chlorinated reaction conditions were: reactant ratio was 1g: 2 m L, solvent DMF dosage was 15 m L, reaction time was 8 h; the optimized amination reaction conditions were: reactant mass ratio was 1:6, reaction temperature was 180 ℃, reaction time was 2.0 h. The process had characteristics such as easily obtained reactants,simple process and environmental friendly etc, which provided a simple synthetic route of 2-amino-1,10- phenanthroline