Indoxamycin家族分子的合成研究进展

Synthetic Progress of Indoxamycin Family

Indoxamycins A^F是从海洋放线菌中分离得到的一类聚酮化合物,它们均含有空间拥挤的[5,5,6]三环类笼状结构和6个连续的手性中心.前期活性研究表明,indoxamycins A和F对HT-29肿瘤细胞株具有显著的生长抑制活性.该综述总结了Carreira和丁寒锋两个小组在此家族天然产物全合成中取得的进展情况.

Indoxamycins A～F represent a novel class of polyketides isolated from the salin cultures of actinomycetes, which contain a common sterically congested [5,5,6] tricyclic cage-like structure featuring six contiguous stereogenic centers. In- doxamycins A and F were reported to exhibit significant growth-inhibition activity against HT-29 tumor cell lines. This review summarizes the synthetic progress towards indoxamycin family members both by the Carreira and Ding groups.