γ-聚谷氨酸衍生物合成研究进展

Progress in Synthesis of γ-polyglutamic Acid Derivatives

目的对γ-聚谷氨酸衍生物的研究背景和合成研究进展展开综述,为γ-聚谷氨酸衍生物的合成提供工作思路。方法通过CNKI、PUBMED、Elsevier等国内外数据库对相关的近年期刊文献,研究成果进行查阅。结果列出了聚谷氨酸衍生物合成方法中主要的四种方法,并综述了合成产物药理作用。结论四种合成方法为合成新型γ-聚谷氨酸衍生物提供了新的思路。开发新型聚谷氨酸衍生物将在未来的医药行业中具备巨大的发展潜力。

OBJECTIVE This paper summarizes the research background,and the current progress in synthetic methods of γ-polyglutamic acid derivatives.It can provide train of thoughts for the development on the sub-ject.METHODS Through the date base including Cnki,PUBMED,Elsevier,and so on,the relevant research pro-gress and the paper published on recent periodicals both at home and abroad were summarized.RESULTS To make a list of four key synthetic routes ofγ-polyglutamic acid derivatives,and review pharmacological actions of these synthesis products.CONCLUSION These synthetic routes provide us new ways and strategies forγ-polyglutamic acid derivatives systhesis.New types ofγ-polyglutamic acid derivatives will apply in the future medical industry with tremendous development potential.