重度妊高征临产前使用长效心痛定联合硫酸镁的临床疗效研究

Clinical Efficacy of Antepartum Use of Long-Acting Nifedipine Combined with Magnesium Sulfate on Severe Pregnancy-Induced Hypertension Syndrome

目的分析重度妊娠高血压综合征(妊高征)产妇临产前使用长效心痛定联合硫酸镁的临床疗效。方法选择60例重度妊高征患者均分为对照组与观察组,所有患者均接受常规治疗,观察组在此基础上接受硫酸镁与长效心痛定联合治疗,观察两组的疗效。结果观察组的治疗总有效率为93.3%,明显高于对照组的70.0%(P<0.05);观察组患者治疗后24 h尿蛋白定量以及平均动脉压指数显著低于对照组(P<0.05);两组的分娩方式差异无统计学意义(P>0.05)。结论产前使用长效心痛定联合硫酸镁治疗重度妊娠高血压综合征可收到满意效果,临床可予以推广使用。

Objective To explore the clinical effect ofantepamam use of long-acting nifedipine combined with magnesium sulfate for severe pregnancy-induced hypertension syndrome. Methods Sixty cases of severe pregnancy-induced hypertension syndrome were divided into the control group and the observation group equally. All patients were given routine therapy, while the observation group was given antepartum use of long-acting nifedipine combined with magnesium sulfate additionally, to compare the clinical effect between the two groups. Results The total effective rate of the observation group was 93.3%, significantly higher than 70.0% of the control group （P〈0.05）. The 24 h urinary protein excretion and mean arterial pressure index of the observation group were significantly lower than those of the control group （P〈0.05）. No significant difference was found between the two groups in delivery mode （_P〉0.05）. Conclusions Antepartum use of long-acting nifedipine combined with magnesium sulfate has significant efficacy for severe pregnancy-induced hypertension syndrome.