阿伦磷酸钠治疗更年期妇女膝关节痛的疗效观察

Efficacy of Alendronate Sodium for the Treatment of Knee Joint Pain of Climacteric Women

目的探讨阿伦磷酸钠治疗更年期妇女膝关节痛的临床疗效。方法选取2011年2月至2013年12月本院治疗的100例更年期妇女膝关节痛患者,随机分为治疗组和对照组各50例,对照组患者单用氨基葡萄糖治疗,治疗组患者采用氨基葡萄糖联合阿伦磷酸钠治疗,比较两组的临床效果及治疗前后视觉模拟评分(VAS)和膝关节关节镜(Lysholm)评分情况。结果治疗后治疗组患者的总有效率为92.0%(46/50),对照组患者的总有效率为72.0%(36/50),两组比较差异有统计学意义(P<0.05)。两组治疗前VAS评分与Lysholm评分差异均无统计学意义(P>0.05);治疗后治疗组患者的VAS评分显著低于对照组患者,Lysholm评分显著高于对照组患者,差异均有统计学意义(P<0.05)。结论氨基葡萄糖联合阿伦磷酸钠治疗更年期妇女膝关节痛,可快速改善患者膝关节肿胀疼痛等临床症状,增强膝关节功能,临床效果显著。

Objective To explore the clinical effect of alendronate sodium for the treatment of knee joint pain of climacteric women. Methods One hundred cases of climacteric women with knee joint pain admitted to our hospital from February 2011 to December 2013 were selected in this study. All cases were randomly divided into the treatment group and the control group, with 50 cases in each group. Patients in the control group were treated with glucosamine, while patients in the treatment group were treated with glucosamine combined with alendronate. The clinical effect, visual analogue scale （VAS） scores before and after therapy, and knee arthroscopy （Lysholm） scores of the two groups were compared. Results The total effective rate of the treatment group was 92.0% （46/50）, significantly higher than 72.0% （36/50） of the control group, and the difference was statistically significant （P 〈0.05）. Before therapy, there were no statistical difference between the two groups in VAS score and Lysholm score （both P 〉0.05）; After therapy, the VAS score of the treatment group was significantly lower than that of the control group, and the Lysholm score of the treatment group was significantly higher than that of the control group, with statistically significant difference between the two groups （both P 〈0.05）. Conclusions Alendronate combined with glucosamine for the treatment of climacteric women with knee joint pain has significant clinical effect, which can quickly improve patients＇ clinical symptoms such as knee swelling and pain, and enhance knee function.