养生功对社区老年2型糖尿病患者氧化应激及生存质量影响

Effects of Chinese Traditional Exercise Baduanjin on Oxidative Stress and Antioxidant Status and Improving Quality of Life in Elderly Type 2 Diabetes Patients in Communities

【目的】探讨不同养生功法对社区老年2型糖尿病（T2DM ）患者氧化应激反应及生存质量的影响。【方法】社区老年T2DM患者200例，随机分为对照组、动功组、动静组和静功组四组。对照组按常规治疗方案不予以养生功干预，后三组均在常规治疗基础上加以不同养生功运动方式干预。测量各组患者在练功前、练功6个月、练功12个月时的生活质量特异性量表（DSQL）；检测各组患者空腹血糖（FPG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、8异前列腺素 F2α（8‐iso PGF2α）、超氧化物歧化酶（SOD），计算胰岛素抵抗指数（HOMA‐IR）。【结果】与对照组相比，练功6个月、12个月后，不同运动干预组生存质量总分、部分维度评分下降（ P ＜0．05， P＜0．01）；与自身练功前相比，动静组与动功组练功12个月后生存质量总评分及生理维度、心理维度下降（ P ＜0．05，P＜0．01）。与对照组比较，动静组及动功组患者练功后6个月、12个月血清 HbA1c、HOM A‐IR水平均下降（ P ＜0．05）；静功组患者练功后12个月血清 HbA1c、HOMA‐IR下降（ P ＜0．05，P ＜0．01）；不同练功干预组练功后6个月、12个月血清8‐iso PGF2α水平均下降，SOD水平均上升（ P＜0．05，P＜0．01）。与自身练功前相比，不同练功组在练功后6个月、12个月SOD水平均上升；动静组与动功组在练功后12个月血清 HbA1c、8‐iso PGF2α、HOMA‐IR水平均下降（ P＜0．05，P＜0．01）；而静功组变化无显著差异。【结论】不同形式养生功可减缓社区老年T2DM患者氧化应激反应，提高患者抗氧化能力，改善患者生存质量。

[Objective] To evaluate the effects of Baduanjin exercise on oxidative stress ,antioxidant status and quality of life in elderly type 2 diabetes mellitus （T2DM ） patients in communities .[Methods]A total of 200 elder‐ly T2DM subjects were recruited to complete a supervised and standardized Baduanjin exercise program thrice weekly for 12 months .8‐isoprostaglandin （8‐isoPG ） level was measured and determined by competitive enzyme immunoassay for oxidative stress .The level of superoxide dismutase （SOD） was measured for antioxidant status . A specific quality of life scale （DSQL） was used to evaluate the changes in quality of life .All outcome measures were collected before intervention and at the end of 6/12 months post‐intervention .[Results] There were signifi‐cant improvements in quality of life after exercising .Greater improvements occurred in different dimensions of DSQL .SOD level significantly increased after exercising .Baduanjin exercise contributed significantly to antioxi‐dant status on these samples .However ,a reduced level of 8‐isoPG was observed .[Conclusion]Baduanjin exercise has the beneficial effects of improving quality of life ,up‐regulating antioxidant enzymes and reducing oxidative stress in elderly T2DM subjects .