不同剂量丙种球蛋白治疗新生儿ABO溶血病临床疗效对比观察

Observation of clinical curative effect of neonatal ABO hemolytic disease with different dose of gamma globulin

目的对比观察不同剂量丙种球蛋白（IVIG）治疗新生儿ABO溶血病的临床疗效。方法对97例出生后1 d、2 d、3-5 d入院的诊断为ABO溶血病的新生儿进行临床回顾性分组研究,其中33例患儿（A组）给予大剂量IVIG（1 g/kg）,33例患儿（B组）给予小剂量IVIG（0.4 g/kg）,31例患者（C组）未使用IVIG,作为临床对照组。观察各组出生后1 d、2 d、3-5 d入院的新生儿经治疗后血清总胆红素（TBIL）的变化。结果在1 d、2 d、3-5 d入院的患儿,血清TBIL水平逐渐升高;经过24 h、48 h的治疗,A组TBIL水平均明显低于B、C组（P〈0.05）。结论早期、大剂量IVIG能够有效降低新生儿ABO溶血病患儿血清TBIL水平,减少黄疸及其后遗症的发生。

Objective To observe and contrast the clinical curative effect of neonatal AVO hemolytic disease with different dose of gamma globulin（IVIG）. Methods The cases of 97 patients with neonatal AVO hemolytic disease after birth 1 d,2 d,3 - 5 d in our hospital were studied retrospectively. 33 cases patients children（group A）were given a high dose of IVIG（1 g/ kg）. 33 patients children（group V）were given low dose of IVIG（0. 4 g/ kg）. 31 patients（group C）without IVIG treatment were used as controls. The change of serum total bilirubin（TVIL）of each group who hospitalized and treated after 1 d,2 d,3 - 5 d birth. Results After 24 hours and 48 hours of treatment,the TVIL level of group A was lower than that in group V and group C（ P 〈 0. 05）. In the first day,the second day,3 - 5 days,the serum TVIL level increased. Conclusion A high dose of IVIG can reduce early the serum TVIL level of patient who have neonatal AVO hemolytic disease effectively,it also can reduce jaundice and sequela.