姜黄素胶囊联合放疗治疗非小细胞肺癌脑转移29例

Curcumin Combined with Radiotherapy for Treating 29 Non- small Cell Lung Cancer Patients with Brain Metastases

目的:探讨姜黄素对NSCLC脑转移治疗效果及对血清VEGF、TNF-α的影响。方法:随机将59例NSCLC脑转移患者分为两组,两组均以适形颅内放疗为基础治疗,观察组自治疗前7天予姜黄素胶囊,比较两组的临床有效率、血清VEGF、TNF-α水平及治疗前后KPS变化、中位生存时间。结果:观察组有效率(37.93%)优于对照组(30%),但两组之间差异无统计学意义(P>0.05);观察组血清TNF-α和VEGF水平较前均下降,但后者差异无统计学意义(P>0.05);KPS评分、中位生存期,对照组均高于对照组,且两指标变化差异有统计学意义(均P<0.05)。结论:姜黄素可控制NSCLC脑转移的临床症状,且有较好的远期疗效,其可能与阻断肿瘤血管生成、控制瘤灶周围炎症等有关。

Objective ： To explore the efficacy of curcumin on non - small cell lung cancer with brain metastases as well as its effect on the expression of serum VEGF and TNF - α. Methods ：59 cases with brain metastases from NSCLC were randomly divid- ed into observation group and control group by digital random table method. Based on the conformal intracranial radiotherapy treat- ment, observation group were given curcumin capsule 100 mg bid oral 7days before the therapy. And then we compared the clinical efficiency, serum levels of VEGF, TNF - a standard between two groups, KPS change and the survival rate. Results ： The clinical ef- ficiency of observation group（37.93% ） was better than that of the control group（30% ）, no statistical significance showed be- tween the two group. Both serum TNF - α and VEGF levels decreased in the observation group, no statistical significance showed in the later indicator （P 〉 0.05）. In the way of KPS scores and TFP, the control group were higher than the treatment group, and the two - parameter change difference was significantly （ all P 〈 0. 05 ）. Conclusion ： Curcumin effect of the treatment of NSCLC with brain metastasis on clinical symptoms and long term effective,it may be associated with tumor angiogenesis and the control- ment of inflammation around the tumor tissue.