疏肝健脾散结方联合GP方案治疗复发转移性乳腺癌的疗效研究

Effect of Chinese Herbal Compound Combining Chemotherapy on Recurrence Breast Cancer

目的:研究探讨疏肝健脾散结方联合GP方案治疗复发转移性乳腺癌的临床疗效。方法:收集符合纳入标准的复发转移乳腺癌患者60例,随机分为观察组与对照组,两组均给予GP方案化疗,但观察组在此基础上服用中药疏肝健脾散结方,化疗两周期后比较两组患者化疗不良反应发生情况、免疫功能改善情况、生活质量变化。结果:观察组较对照组化疗不良反应虽血小板减少及肝肾功损害差异不显著(P>0.05),但白细胞减少、恶心呕吐明显轻于对照组(P<0.05);经治疗观察组免疫功能改善情况、生活质量提高情况、肿瘤标志物CEA及CA153降低情况均明显优于对照组(P<0.05)。结论:疏肝健脾散结方联合GP方案治疗复发转移性乳腺癌可减轻化疗毒副反应,改善患者机体免疫力,提高生活质量,降低肿瘤标志物CEA及CA153,效疗肯定。

Objective ： To research the clinical effect of Chinese herbal compound combining chemotherapy on recurrence breast cancer. Methods ：60 recurrence breast cancer cases were grouped randomly as treatment group and control group. All were treated by gemcitabine and cisplatin, and the treatment group was combined with Chinese herbal compound. After 2 cycles of chemothera- py, we observed the toxic and side effect, immunological factors, tumor markers and the quantify of life. Results ： On the toxic - side effect and liver function damage, treatment groups showed no difference compared with control group （ P 〉 0.05 ）. But on increas- ing immunological factors,improving the quantify of life, decreasing the expression of CEA and CA153, relieving the low white blood cell and nausea, treatment groups showed significant difference compared with control group （ P 〈 0. 05 ）. Conclusion ： Chi- nese herbal compound combining chemotherapy could increase immunological factors, improve the quantify of life and decrease the expression of CEA and CA153.