摘要
目的:研究四逆散及其不同拆方对实验性溃疡性结肠炎大鼠IL-4的影响。方法:将实验动物分为14组,采用免疫法造模,以大鼠一般状况、结肠组织大体情况、结肠组织病理变化和实验大鼠IL-4活性作为观察与检测指标。结果:四逆散及其拆方能够降低实验大鼠IL-4的含量,其中四逆散全方作用最佳,明显高于其各拆方组;各拆方组组间比较,柴芍枳配伍与柴芍配伍作用最强,去除柴胡或白芍后的芍枳甘配伍与柴枳甘配伍降低血清IL-4含量的作用降低,所不同的是柴枳甘配伍增加UC实验大鼠结肠黏膜IL-4的作用与柴芍枳配伍、柴芍配伍的作用并无显著差异,而芍枳甘组降低结肠黏膜IL-4含量的作用同样低于柴芍枳配伍、柴芍配伍。结论:四逆散及其拆方能够通过调节实验性UC大鼠血清及结肠黏膜IL-4活性来干预UC,方中柴胡、芍药调节实验性UC大鼠IL-4活性的作用在四逆散全方中占有重要地位。
Objective:The study is the Sini powders and the different compatibilities in influence on IL -4 of experimental ul- cerative colitis rats. Methods:The experimental animals were divided into 14 groups and modeled with immunization. Through ob- serving and detecting the states, pathological changes varying, activity of IL -4 of rats. Results:Sini and the different compatibili- ties can reduce the action of IL - 4 in rats, in which the whole side effect Sini was the best, significantly higher than the others. A- mong in the different compatibilities groups, the action of the IL - g of UC rats in the Chaishaozhi groups and Chaishao group were significantly higher than that of the other groups, but Chaizhigan group and Shaozhigan group were significantly lower than the oth- ers. Conclusion :Sini and the different compatihi[ities could adjust the action of the IL-4 of the colonic mucosa and serum of the experimental UC rats, and arguably Chaishao, Bupleurum and Peony, as monarch drug and ministerial drug in the prescription play the important roles.
出处
《辽宁中医杂志》
CAS
北大核心
2015年第5期1122-1124,I0001,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
教育部高等学校博士学科点专项科研基金课题(新教师类)(20122133120009)
辽宁省教育厅项目(2006T094)
关键词
四逆散
拆方
溃疡性结肠炎
实验
IL-4
Sini Powders
compatibility
ulcerative Colitis
experiments
IL - 4