单、双相抑郁障碍认知功能损害的比较

A comparison of cognitive function between patients with unipolar depression and bipolar depression

目的比较单、双相抑郁障碍患者认知功能损害的程度和种类,以探讨单、双相抑郁障碍认知功能损害的差异。方法对来源于武警山西总队医院2011-03至2014-02门诊和住院的符合入组标准的30例单相抑郁和28例双相抑郁患者,于急性起病期进行汉密尔顿抑郁量表评估,采用中国修订韦氏成人智力测验量表、威斯康星卡片分类测验进行神经心理学测量,并与30例健康对照组进行比较,观察神经心理测验各指标的变化。并对单、双相抑郁患者认知功能各指标与汉密尔顿抑郁量表各因子行简单相关分析。结果在认知功能测验中,单、双相抑郁障碍与健康对照组相比差异均有统计学意义(P<0.05);单相抑郁、双相抑郁障碍患者相比在操作智商方面差异有统计学意义(P<0.05)。单相抑郁患者焦虑/躯体化因子与言语量表呈负相关(P<0.05),认知功能与言语量表和操作量表呈负相关(P<0.01);双相抑郁患者躯体化/焦虑与相似、词汇成负相关(P<0.05)、与操作量表分呈负相关(P<0.01),认知功能与操作量表呈负相关。结论单、双相抑郁障碍患者均存在广泛的认知功能损伤,且与临床特征表现存在一定的相关性。但损害存在差异,双相抑郁障碍患者在操作智商方面损害略低于单相抑郁。

Objective To study significant cognitive function indicators which can help early diagnose bipolar depression by comparing the cognitive function between patients with bipolar depression and unipolar depression. Methods Unipolar depression group and bipolar depression group from the inpatients and outpatients of Armed Police corps hospital in Shanxi Province, had the tests in acute stage, including Scale for assessment of clinical symptoms as HAMD ; neuropsychological test, as WAIS, WCST. Normal con- trol group had the neuropsyehological test compared with patients. And the relationships between neuropsychol ogical ＂tests and clinical variables were tested using correlation analysis. Results Compared with normal control group, patients have cognition dysfunction; there were differences between unipolar depression and bipolar depression patients in performance intelligence quotient. Some factors of HAMD were negatively correlated to WAIS scales in patients. Conclusions It is common that unipolar depression patients and bipolar depression patients have different cognition disfunction which is correlated to clinical features. Bipolar depression cognitive impairment is slightly lighter than unipolar depression in the acute onset.