糖尿病前期的代谢综合征患者发生肾损害的临床分析

Clinical analysis of kidney damage in metabolic syndrome patients with prediabetes

目的分析糖尿病前期的代谢综合征(MS)患者发生肾损害情况及临床特点。方法选取2014年1月至10月住院的MS合并2型糖病或糖尿病前期的患者。统计肾损害的临床特征,依糖代谢异常程度分组比较肾损害的患病率。结果 531例MS患者中糖尿病组439例,肾损害患病率为54.0%,糖尿病前期组92例,肾损害患病率为46.7%,2组比较差异无统计学意义(P>0.05)。糖尿病前期组中出现肾功能下降占29.4%,蛋白尿占25.0%,血尿占2.2%,B超下肾脏改变为1.1%。除蛋白尿及显性蛋白尿外,其余肾损害患病率差异在2组间比较差异无统计学意义。结论 MS住院患者在糖代谢异常的早期阶段糖尿病前期时肾损害的患病率即已较高,主要临床表现为肾功能不全和蛋白尿,需提早对此类人群的肾损害情况进行评估。

Objective To explore the prevalence and clinical manifestation of kidney damage in metabolic syndrome patients with prediabetes.Methods Five hundred and thirty one patients in hospital with metabolic syn‐drome and disorder of glycolmetabolism were studied from January to October 2014 .We investigated the preva‐lence of kidney damage and clinical characteristics of these patients ,and compared the prevalence of kidney damage among prediabetes and T2DM groups.Results The prevalence of kidney damage was 54.0% in T2DM group and 46.7% in prediabetes group .The difference between two groups had no statistic significance （ P 〉0.05） .The prevalence of reduced renal function ,proteinuria ,hematuria ,and kidney image change under B‐mode ultrasonog‐raphy in prediabetes group was 29.4% ,25.0% ,2.2% ,1.1% ,respectively .The prevalence of kidney damage between T2DM group and prediabetes group had no difference with statistic significance except for proteinuria and dominant proteinuria.Conclusion Kidney damage was common in metabolic syndrome patients with prediabetes characterized by reduced renal function and proteinuria .