宁养肺癌患者的生存分析

SURVIVAL ANALYSIS OF PATIENTS WITH LUNG CANCER IN HOSPICE CARE

目的:通过对宁养院肺癌患者临床资料的收集和统计分析,探讨影响肺癌患者预后生存的独立影响因素。方法:收集广西医科大学第一附属医院宁养院2010年1月至2012年12月期间收治的284例肺癌患者的病历资料,并进行随访调查及回顾性研究,采用Kaplan-Meier法计算生存期和绘制生存曲线,组间比较采用log-rank检验,多因素分析采用Cox比例风险模型。结果:宁养肺癌患者的平均生存期为12.0个月,中位生存期为8.5个月,6个月累积生存率为(65.7±2.8)%,1年累积生存率为(35.4±2.9)%,3年累积生存率为(4.6±1.4)%。单因素分析显示,性别、文化程度、是否接受过手术治疗、化疗、放疗、出现疼痛的时间和疼痛治疗史影响患者的生存期;Cox回归分析显示,性别、文化程度、是否接受过手术治疗、放疗和出现疼痛的时间是影响宁养肺癌患者预后的独立影响因素。结论:宁养肺癌患者生存期相对较短,影响其预后生存的独立影响因素有性别、文化程度、是否接受过手术治疗、放疗和出现疼痛的时间。

Objective： To collect and analyze the clinical datas of lung cancer, so that investigate the inde- pendent influenced factors for survival in lung cancer. Methods： 284 patients with lung cancer who received service of hospice care from January 2010 to December 2012 were taken part in follow-up survey and retro- spective analysis. Meanwhile, Survival time was analyzed and survival curve was drawn by Kaplan-Meier method while Log-rank test was adoptep for comparison between groups. Furthermore, Multivariate analysis of variables was performed by the Cox proportional hazard regression model. Results：The average survival time of all the patients was 12.0 months and the median survival time was 8.2 months. The 6-month cumulative survival rate was （65.7±2.8）%, the 1-year cumulative survival rate was （35.4±2.9）% and the 3-year cumulative survival rate was （4.6±1.4）%. Univariate analysis showed that the gender, educa- tional level, receiving relative operations or not, chemotherapy, radiotherapy, time of pain appearing and past histories of treatment of pain, were the factors affecting the survival of patients with lung cancer. Multivariate analysis showed that gender, educational level, receiving relative operations or not, radiotherapy and time of pain appearing were the independent factors affecting the survival time of lung cancer. Conclusion：The survival time of patients with lung cancer in hospice care is relatively short, And Gender, educational level, receiving operations or not, radiotherapy and time of pain appearing are independent prognostic factors affecting the the survival time of patients with lung cancer.