血液透析患者勃起功能障碍影响因素的临床调查分析

Influencing factors of erectile dysfunction in hemodialysis patients

目的:探讨影响男性血液透析患者勃起功能障碍的因素。方法:选取2011年8月至2013年8月收治入院的125例已婚男性血液透析患者为研究对象,根据是否发生勃起功能障碍将其分为两组,发生勃起功能障碍的79例患者为观察组,未发生勃起功能障碍的46例患者为对照组;比较两组患者的临床资料和性激素水平,同时对发生勃起功能障碍的患者其进行Logistic多因素回归分析。结果:两组患者在年龄、透析期间肌酐、血清磷、血清总钙、透析充分性、β-受体阻滞剂每日服用量、IIEF问卷得分、生活质量总分及抑郁得分等资料进行比较,差异有统计学意义(P<0.05);观察组透析期间的性激素水平分别为睾酮(3.12±1.89)ug/L、泌乳素(889±2602)m IU/L、黄体生成素(19.3±4.12)IU/L、促卵泡激素(21.8±6.22)IU/L、雌二醇(95.8±21.76)ng/L,与对照组激素水平比较,两组差异有统计学意义(P<0.05);Logistic多因素回归分析进一步表明,高龄、β-受体阻滞剂、抑郁程度、生活质量和性激素水平是男性血液透析患者勃起功能障碍的独立影响因素。结论:男性血液透析患者勃起功能障碍与β-受体阻滞剂、激素水平、高龄、抑郁程度和生活质量等因素密切相关,临床治疗和干预时需充分考虑上述因素。

Objectives：To investigate the influencing factors of erectile dysfunction in hemodialysis pa-tients.Methods：125 married men with hemodialysis in our hospital from August 2011 to August 2013 were selected and divided into two groups based on their erectile function：79 cases of ED in observation group,and 46 cases of normal erectile function in control group.The clinical data and sex hormone levels of two groups were analyzed com-paratively.Multi -factor logistic regression analysis was performed in ED patients.Results：The difference in ages, creatinine during hemodialysis,serum phosphorus,serum total calcium,dialysis adequacy,quality of life scores and depression scores and other general information between two groups were statistically significant （P 〈0.05）. The sex hormone levels in observation group were higher than that in control groups （P 〈0.05）.Logistic regression analysis further suggested that the elder age,β- blockers,the degree of depression,quality of life and sex hor-mone levels were independent factors for hemodialysis patients with erectile dysfunction.Conclusion：β- block-ers,hormone levels,age,severity of depression and quality of life and other factors are closely related to erectile dysfunction in patients with hemodialysis.Treatment and intervention need to fully consider the above factors.