摘要
Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of Aβ with multiple weak interactions is better than those that only target a single region with the single driving force mainly.
Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of Aβ with multiple weak interactions is better than those that only target a single region with the single driving force mainly.
基金
financially supported by the National Natural Science Foundation of China(Nos.20634030 and 51273094)
State Key Fundamental R&D Project(No.2011CB606202)
PCSIRT(No.IRT1257)
