PHB及mPEG-PHB嵌段共聚物的合成与表征

Synthesis and Characterization of PHB and Block Copolymer mPEG-PHB

以β-丁内酯(BL)为单体、萘钾-冠醚为引发剂通过阴离子开环聚合合成聚(β-丁内酯)(PHB),研究了反应时间对PHB分子量的影响。在萘钾-冠醚引发体系的基础上制备聚乙二醇甲醚-钾大分子引发剂(mPEG-K),采用mPEGK引发β-丁内酯开环聚合合成两亲性嵌段共聚物聚乙二醇甲醚-聚(β-丁内酯)(mPEG-PHB),并通过1 HNMR、FTIR、DSC对其进行表征。通过分子自组装技术制备了mPEG-PHB共聚物的纳米粒子,采用SEM、TEM、DLS对纳米粒子进行表征。结果表明,在一定时间内PHB的分子量随反应时间的延长而增大。DSC结果表明,无定形的PHB明显降低了结晶性mPEG的结晶能力。mPEG-PHB纳米粒子为粒径在100nm左右的具有核壳结构的纳米微球。

Usingβ-butyrolactone（BL）as monomer,naphthalene potassium-crown ether as initiator,poly（β-butyrolactone）（PHB）was synthesized by anionic ring-opening polymerization.The effect of reaction time on molecular weight of PHB was studied.Poly（ethylene glycol）methyl ether-potassium macroinitiators（mPEG-K） was synthesized based on naphthalene potassium-crown ether.Amphiphilic poly（ethylene glycol）methyl ether-poly（β-butyrolactone）（mPEG-PHB）was prepared by ring-opening polymerization of BL initiated by mPEG-K. Copolymer was characterized by 1 HNMR,FTIR,DSC.The copolymer nanoparticles were prepared by the mo-lecular self-assemble technology.These nanoparticles were characterized by SEM,TEM,DLS.The results showed that the molecular weight of PHB increased with reaction time in a certain time.The DSC results showed that amorphous PHB reduced the crystallization ability of mPEG significantly.These nanoparticles were core-shell structure nanospheres with size of 100 nm.