87例泛发性脓疱型银屑病住院患者临床分析

The clinical analysis of 87 hospitalized patients with generalized pustular psoriasis

目的探讨分析泛发性脓疱型银屑病（generalized pustular psoriasis,GPP）住院患者的临床、病理特征及治疗。方法回顾性分析广东省汕头市皮肤性病防治院87例确诊的GPP住院患者的发病诱因、临床病理特征及治疗。结果本地区GPP患者以30~60岁居多,诱发因素主要为上呼吸道感染和皮质类固醇激素的不当使用;临床表现为泛发性无菌性小脓疱,常伴发热、中性粒细胞升高、低白蛋白血症、C反应蛋白升高等;组织病理表现为表皮内海绵状脓疱;阿维A为首选治疗药物。结论 GPP的发病多有诱因或加重因素,组织病理学检查可协助诊断,治疗以阿维A为主,慎用皮质类固醇激素。

Objective To discuss and analyze the clinic pathological features and treatment of hospitalized patients with generalized pustular psoriasis（GPP）. Method Medical records of 87 hospitalized patients diagnosed with GPP were collected. Predisposing factors, clinic pathological features and treatment of patients with GPP were analyzed retrospectively. Result Majority of local patients with GPP were between 30 to 60 years old with the main predispo- sing factors of upper respiratory tract infection and improper use of corticosteroid. Clinical characteristics included generalized aseptic pustules often accompanied by fever, increase in neutrophils and C-reactive protein, hypoalbu- minemia and so on. Histopathological examination was characterized by intraepidermal cavernous pustules, with aci- tretin as the preferred drug. Conclusion GPP often accompanied with predisposing or aggravating factors can be di- agnosed with the assistance of histopathological examination. As the preferred treatment of choice, acitretin should be considered with corticosteroid used cautiously.