艾滋病患者304例抗病毒治疗病毒学效果及其影响因素分析

Analysis of virology effect and influence factors of 304 AIDS patients′antiviral therapy

目的了解接受艾滋病抗病毒治疗病例特点和治疗后病毒学效果,分析影响病毒学效果的因素。方法在国家艾滋病综合防治信息系统中收集资料,回顾性观察既往治疗病例病毒学效果,从而进行统计分析。结果 304例治疗患者中,近3个月出现药物毒副反应占5.3%,漏服药物超过3次占4.9%。治疗6个月后,病毒载量成功抑制者占93.4%,病毒载量抑制失败者占6.6%。多因素Logistic回归分析结果显示,静脉注射吸毒感染、WHO分期Ⅳ期患者、药物毒副反应、漏服药品为艾滋病患者治疗病毒学失败的影响因素。结论抗病毒治疗病毒学效果较好,还应针对病毒学失败影响因素采取措施,进一步提高抗病毒治疗成功率。

Objective To know the characteristics of cases recieving anti-HIV therapy and the virology effect after treatment, and to analyze the risk factors affecting the virology effect. Methods Collected the data from the National AIDS Integrated Control Information System. Retrospectively observed past cases＇ virology effect in order to do a statistical analysis. Results 5.3% had drug toxicity and 4.9% missed drug taking more than 3 times during the near 3 months. 93.4% successfully suppressed the viral load while 6.6% failed after 6 months of treatment. Multi-factor Logistic regression analysis showed that intravenous drug abuse infection,WHO classification stage IV patients, drug toxicity and missing drugs were the influencing factors antiviral therapy failure. Conclusion Antiviral therapy has a good virology effect. Measures aiming at factors causing virology failure should be taken in order to increase the success rate of antiviral therapy.