全氟辛烷磺酸的海马神经毒性研究进展

Research Progress on Neurotoxicity of Perfluorooctane Sulfonate to Hippocampus

全氟辛烷磺酸(PFOS)在生活中广泛存在,具有全球性、持久性、富集性等特征,具胚胎发育、生殖、免疫、神经和肝脏等多种毒性,其中神经毒性倍受关注。近期研究结果显示,PFOS的神经毒性主要集中在大脑皮质、脑干、海马脑区。本文就PFOS对海马脑区神经毒性的研究加以归纳总结,在近期研究进展的基础上讨论了PFOS对神经传导通路中各成分稳态的改变,进而了解PFOS对海马脑区神经损害的机制。

Perfluorooctane sulfonate（PFOS） is a widespread chemical in the living environment, featuring globalization, persistence, and accumulation. The impacts to the ecological system include embryo toxicity, reproductive toxicity, immunotoxicity, neurotoxicity, and hepatotoxicity, among which neurotoxicity is of great concern. Recent studies have shown that the neurotoxicity of PFOS mainly concentrates in brain regions such as cerebral cortex, brainstem, and hippocampus. This paper inducts and summarizes studies regarding the neurotoxicity of PFOS to hippocampus. Based on recent research progress, the steady-state changes of each component in neural pathways induced by PFOS are also discussed to further understand the mechanism of nerve damage in hippocampus caused by PFOS.