肝X受体抗动脉粥样硬化作用机制研究进展

Research progress on antiatherosclerosis mechanism of liver X receptors

肝X受体是配体激活的核受体转录因子超家族成员,在脂质代谢中起关键的调控作用。在过去的10年中,大量研究表明,肝X受体通过激活或抑制其靶基因,参与一系列代谢和炎症反应的生理过程,从而与心血管疾病紧密联系。肝X受体在对抗动脉粥样硬化发展过程中的作用日益突出,为此本文就在动脉粥样硬化发病机制中肝X受体信号通路所涉及的靶点进行综述。

Liver X receptor is a ligand -activated transcription factor of nuclear receptor super family .It played a key role in the regulation of lipid metabolism.In the past decade , numerous studies show that liver X receptor are involved in a series of physiological processes such as meta-bolism and inflammation by activating or inhibiting its target genes that are so closely linked with cardiovascular diseases .In recent years, a large number of studies have shown that liver X receptor are increasingly prominent in fighting against atherosclerosis . In this paper , we will review the targets of the LXR pathways on the pathogenesis of atherosclerosis.