代谢综合征“痰证”与易感基因相关性研究进展

Research Progress of the Correlation between Phlegm Syndrome and Susceptibility Genes in Metabolic Syndrome

代谢综合征(metabolic syndrome,MS)是一种多基因遗传的复杂疾病,由多个基因累加作用和某些环境因素影响所致。胰岛素抵抗是其病理生理基础。从中医学角度看,痰是MS共同的证候病理特点,痰的病理贯穿MS全过程。基因作为先天因素的重要组成部分,在痰证的形成中发挥重要作用。研究MS痰证与易感基因的相关性,对于进一步丰富痰证的内涵、提高本病诊疗水平具有十分重要的意义。

Metabolic syndrome （MS） is a complex polygenic inheritance disease, caused by the accumulative effect of multiple genes and some environmental factors. Insulin resistance is the pathophysiologic foundation of MS. From the viewpoint of TCM, phlegm is the basic pathological factor of MS. In different periods and different symptoms of the disease, phlegm can be found during the whole disease course. Genes as an important component of the innate factors, play an important role in the formation of phlegm syndrome. Researches on correlation between susceptibility genes and phlegm syndrome in MS are important to enrich the connotation of phlegm syndrome and improve the level of diagnosis and treatment for this disease.