血清胃蛋白酶原测定在胃病诊断中的价值

Value of serum pepsinogen determination in diagnosis of gastric diseases

目的观察血清胃蛋白酶原(PG)测定在胃疾病诊断中的应用效果。方法选取2012-02—2014-03参加体检的153例胃疾病患者,采用乳胶增强免疫化浊法测定PG。按不同疾病分5组,分别为糜烂性胃炎组、十二指肠溃疡组、胃溃疡组、萎缩性胃炎组、胃癌组,另取对照组。对比分析6组间的差异。结果糜烂性胃炎组、十二指肠溃疡组和胃溃疡组分别与对照组相比较,血清PGⅠ、PGⅡ含量及PGⅠ/PGⅡ比值比较高,差异有统计学意义(P<0.05);萎缩性胃炎组、胃癌组分别与对照组相比较,血清PGⅠ、PGⅡ含量及PGⅠ/PGⅡ比值比较低,差异有统计学意义(P<0.05)。结论 PG在不同胃疾病中浓度和比值均不同,对诊断疾病具有一定的临床价值。

Objective To observe the application effect of serum pepsinogen（PG）determination in diagnosis of gastric diseases. Methods 153 cases with gastric diseases taking physical examination in our center from February 2012 to March 2014 were selected and given serum pepsinogen determination by means of latex-enhanced immunoturbidimetry.According to different diseases,they were divided into five groups,including erosive gastritis group,duodenal ulcer group,gastric ulcer group,atrophic gastritis group,and gastric cancer group.A control group was set up.Then the differences between the six groups were compared and analyzed. Results The PG Ⅰ,PG Ⅱ and PG Ⅰ /PG Ⅱ in erosive gastritis group,duodenal ulcer group,and gastric ulcer group were higher than those in the control group,and the differences were of statistical significance（ P 〈0.05）.The PG Ⅰ,PG Ⅱ and PG Ⅰ /PG Ⅱ in atrophic gastritis group and gastric cancer group were lower than those in the control group,and the differences were of statistical significance（ P〈0.05）.Conclusion Different concentration and ratio of serum pepsinogen occur in different gastric diseases,which has certain clinical value in the diagnosis of diseases and is worth popularization and application.