不同剂量螺内酯对难治性心力衰竭患者心功能影响分析

Analysis of influence by different spirolactone doses on cardiac function in refractory heart failure patients

目的探究不同剂量的螺内酯对难治性心力衰竭患者心功能的影响。方法 180例心力衰竭患者作为研究对象,将其随机分为低剂量治疗组(甲组)和高剂量治疗组(乙组),各90例。分别进行螺内酯20 mg/d和40 mg/d治疗,比较两组患者治疗前后的心功能指标。结果所有患者服用螺内酯药物后心功均有所改善,同时乙组患者的心功能指标明显优于甲组,差异具有统计学意义(P<0.05)。结论在难治性心力衰竭患者的临床药物治疗中,40 mg/d螺内酯的治疗作用更加明显,更有助于患者心功能的改善,值得临床应用。

Objective To explore influence by different spirolactone doses on cardiac function in refractory heart failure patients.Methods A total of 180 heart failure patients as study subjects were randomly divided into low dose treatment group （group A） and high dose treatment group （group B）, with 90 cases in each group. They respectively received 20 mg/d and 40 mg/d of spirolactone for treatment. Cardiac function indications of the two groups were compared before and after treatment.Results All patients had improved cardiac function after spirolactone administration, while the group B had much better cardiac function indications than the group A. The difference had statistical significance （P〈0.05）.Conclusion Implement of 40 mg/d of spirolactone provides much obvious effect in clinical drug treatment for refractory heart failure patients, and this method is helpful for their cardiac function improvement. It is worth clinical application.