美洛昔康在骨科术后的镇痛疗效及其安全性分析

Analysis of analgesic effect and safety of meloxicam after orthopedic surgery

目的探讨美洛昔康在骨科术后的镇痛效果,评价其安全性。方法 136例骨科手术患者为研究对象,A组(62例)大型手术,B组(42例)中型手术,C组(32例)小型手术,三组术后均予以美洛昔康镇痛,视觉模拟评分(VAS)评价镇痛效果,监测用药前后血常规、肝功能,统计不良反应事件。结果三组用药后VAS评分均明显好于用药前,差异具有统计学意义(P<0.05),A、B、C三组用药48 h后的疼痛缓解率分别为58.06%、76.19%和84.38%,芬太尼使用率分别为33.87%、16.67%和3.13%,B、C组的镇痛效果明显好于A组(P<0.05);用药前后所有患者血常规和肝功能比较,差异无统计学意义(P>0.05),无严重不良反应。结论美洛昔康在中小型骨科手术中的术后镇痛效果良好,安全性佳,值得临床推广应用。

Objective To investigate analgesic effect of meloxicam after orthopedic surgery, and to evaluate its safety.Methods There were 136 patients under orthopedic surgery as study subjects. Group A （62 cases） received major surgery, group B （42 cases） received medium surgery, and group C （32 cases） received minor surgery. All three groups received meloxicam in postoperative analgesia, and the analgesic effects were evaluated by visual analogue scale （VAS）. Monitoring was made on blood routine examination and liver function after treatment, and adverse reactions were summarized.Results All three groups had much better VAS scores after treatment than those before treatment, and their difference had statistical significance （P〈0.05）. Pain relief rates after 48 h treatment were respectively 58.06%, 76.19%, and 84.38% in groups A, B and C. Their fentanyl use rates were respectively 33.87%, 16.67% and 3.13%. Groups B and C had obviously better analgesic effects than group A （P〈0.05）. There were no statistically significant differences of blood routine examination, and liver function before and after treatment （P〉0.05）. No severe adverse reactions were found.Conclusion Meloxicam provides good analgesic effect and safety after medium surgery and minor surgery, and it is worthy of clinical promotion and application.