太原市PM2.5对哮喘患者炎症反应的季节性影响

The seasonal effects of PM2.5 particles on inflammatory reaction of patients with asthma in Taiyuan

目的探讨太原市PM2.5对哮喘患者机体炎症因子的季节影响。方法以太原市不同社区哮喘患者29例为研究对象,在2013年分春、夏、秋三季对其生活环境PM2.5监测1周,并采集血样检测炎症因子。统计分析采用方差分析及非参数检验。结果哮喘患者春季室外PM2.5[(185.89±37.30)μg/m3]、室内PM2.5[(170.30±23.84)μg/m3]和个体PM2.5暴露值[(186.91±35.66)μg/m3]均高于相应秋季暴露值(148.48±26.40,77.50±9.43,82.11±8.46)μg/m3(P<0.05);哮喘患者血浆春季COX-2浓度19.60(6.36)μg/L高于秋季浓度10.73(3.96)μg/L,春季Eotaxin浓度9.43(2.78)ng/L高于秋季浓度5.42(1.57)ng/L,春季IL-10浓度3.24(1.55)ng/L低于秋季5.45(1.37)ng/L(P<0.012 5);室外PM2.5浓度、室内PM2.5暴露浓度以及个体PM2.5浓度与COX-2、Eotaxin呈正相关(P<0.05),与IL-10呈负相关(P<0.05)。结论 PM2.5可能通过影响哮喘患者机体相应炎症因子的表达加重哮喘疾病。

Objective To discuss the seasonal effects of PM2.5particles on inflammatory reaction of patients with asthma in Taiyuan. Methods PM2.5particles were monitored around living environment of 29 patients with asthma from different communities for a week during spring,summer and autumn in 2013,and blood samples were collected for the detection of inflammation related cytokines.ANOVA and non-parametric tests were used for data statistical analysis. Results The indoor,outdoor and personal PM2.5exposure concentrations in spring（185.89±37.30,170.30±23.84,186.91±35.66）μg/m3 were higher than that in autumn（148.48±26.40,77.50±9.43,82.11±8.46）μg/m3（P〈0.05）.COX-2and Eotaxin concentrations of asthma patients in spring were higher than that in autumn [19.60（6.36）μg/L vs 10.73（3.96）μg/L;9.43（2.78）ng/L vs 5.42（1.57）ng/L]（P〈0.05）,while,IL-10 concentrations in spring were lower than that in autumn[3.24（1.55）ng/L vs 5.45（1.37）ng/L]（P〈0.012 5）.The indoor,outdoor and individual PM2.5exposure concentrations were positively correlated with serum levels of COX-2and Eotaxin（P〈0.05）,while negatively correlated with IL-10level（P〈0.05）. Conclusions PM2.5particles may influence the expression of some inflammatory cytokines and then exacerbate the severity of asthma.