短暂性脑缺血发作生物学标志物研究进展

Development of Biomarkers of Transient Ischemic Attack

短暂性脑缺血发作(transient ischemic attack,TIA)是卒中的危险预警信号。至今尚无公认的对卒中风险预测价值高的TIA的生物学标志物。寻找快速而准确的TIA后卒中风险的生物学标志物是目前研究的热点。本文从应激激素、炎症因子、血栓形成因子等方面对TIA后卒中风险的生物学标志物研究进行综述,并简要介绍基因测序及代谢组学等方法在TIA后卒中风险预测中的应用。

Transient ischemic attack （TIA） is an early-warning alarm for stroke. As of yet, no known blood marker reliably predicts stroke risk after TIA. The present research focuses on TIA biomarkers to identify high risk patients rapidly and accurately. In this article, we provide a review on the development of TIA biomarkers involving stress hormones, inlfammatory factors, thrombosis factors. Meanwhile, the paper gives a brief introduction about gene sequencing and metabonomics methods in the application of stroke risk prediction after TIA.