黄色肉芽肿性胆囊炎23例临床病理分析

Xanthogranulomatous cholecystitis:A Clinical and Pathological analysis of 23 Cases

目的探讨黄色肉芽肿性胆囊炎(xanthogranulomatous cholecystitis,XGC)的临床病理特点及诊断要点。方法回顾性分析23例XGC患者的临床与病理资料。结果 23例XGC均为老年人,女性多见。临床表现类似一般的胆囊炎或胆石病,所有患者术前均误诊为胆囊炎或胆囊癌。XGC病变多位于胆囊体部,病理学检查是在胆囊壁内形成特征性泡沫状细胞性肉芽肿,术后病理诊断为XGC。结论 XGC临床症状不典型,常在术前难以诊断,极易造成误诊,应引起高度重视。

Objective To study the clinicopathologic characteristics of xanthogranulomatous cholecystitis and to study the diagnostic criteria of this disease. Methods The clinical and pathologic data of 23 patients with XGC, who were treated were retrospectively analyzed. Results All were elderly patients,especially the females. The clinical presentation was similar to that of general chronic cholecystitis or cholelithiasis. All patients were misdiagnosed preoperatively as cholecystitis or gallbladder carcinoma. Most of lesions located in gallbladder body. Histologically,the foam cell granuloma in gallbladder was the characteristic pattern. XGC was definitely diagnosed by postoperative pathological examination in all of patients. Conclusion XGC is usually difficult to diagnose preoperatively because of its atypical clinical manifestations,which easily result to misdiagnosis. More attention should be paid to this.