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非经典HLA-Ⅰ类分子对母胎免疫耐受的调节 被引量：8

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摘要 携带父系抗原的胚胎作为植入母体子宫腔内的半同种异体移植物,却不被母体排斥,有赖于母胎间复杂的免疫耐受。一旦母胎免疫耐受不足或缺失就可能导致反复妊娠丢失等病理性妊娠的发生。在正常妊娠过程中,胎儿绒毛外滋养细胞可特异性高表达非经典HLA-I类分子HLA-E、HLA-F、HLA-G,对母胎界面免疫耐受的维持及调节发挥着关键作用。
作者 刘翠莲 崔澂 王利飞 郝淑维
机构地区 河北医科大学第四医院妇产科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2015年第5期711-714,共4页 Chinese Journal of Immunology
关键词 HLA-Ⅰ类分子 母胎免疫耐受 调节 绒毛外滋养细胞 同种异体移植物 HLA-G 反复妊娠丢失 妊娠过程
分类号 R321.3 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献35

  • 1Rizzo R,Vereammen M,van de Velde H,et al. The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells[J]. Cell Mol Life Sci,2011,68(3) :341-352.
  • 2蒋红丽,王慧,杨冬,付稳,刘陶.HLA-G在子痫前期患者胎盘中的表达及意义[J].中国医刊,2012,47(6):86-89. 被引量：7
  • 3Guillard C, Zidi L, Marcou C, et al. Role of HLA-G in innate immunity through direct activation of NF-KB in natural killer cells [ J ]. Mol Immunol,2008,45 (2) :419-427.
  • 4Yu Y, Wang Y, Feng M. Human leukocyte antigen-G1 inhibits natural kller cytotoxicity through blocking the activating signal t transduction pathway and formation of activating immunologic synapse[ J ]. Hum Immuno1,2008,69 ( 1 ) : 16-23.
  • 5Fainardi E, Castcllazzi M, Stignani M, et al. Emerging topics and flew perspectives oft HLA-G[ J]. Cell Mol Life Sci ,2011,68 (4) : 433-451.
  • 6Li C, Houser BL,Nicotraml L, et al. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells[ J]. Proc Natl Acad Sci USA, 2009,106 (14) :5767-5772.
  • 7Rajagopalan S. Endosomal signaling and a novel pathway defined by the natural killer receptor KIR2DIA ( CDI58d ) [ J ]. Traffic, 2010,11 ( 11 ) :1381-1390.
  • 8Favier B, Lemaoult J, Lesport E, et al. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse [ J ]. FASEB J, 2010,24(3) :689-699.
  • 9Morandi F, Ferretti E, Bocca P,et al. A novel mechanism of soluble HLA-G mediated immune modulation: downregulation ~f T cell chemokine receptor expression and impairment of chemotaxis. PLoS One,2010,5 (7) : el 1763.
  • 10Naji A, Menier C, Morandi F, et al. Binding of HLA-G to ITIM- Bearing Ig-like Transcript 2 Receptor Suppresses B Cell Responses[ J ]. J Immunol,2014,192 (4) : 1536-1546.

二级参考文献27

  • 1刘礼兵,刘云,何华庆,李永辉,徐琪寿.qa-3稀有密码子和mRNA结构改造及其在大肠杆菌中的高效表达[J].生物工程学报,2006,22(2):198-203. 被引量：17
  • 2王晨虹.早发型重度子痫前期的特点和诊治[J].中国医刊,2007,42(6):4-6. 被引量：8
  • 3Moseoso J, Serrano-Vela JI, Paeheeo R, et al. HLA-G, -E and-F: allelism, function and evolution. Transpl Immunol, 2006;17(1):61-64.
  • 4Rizzo R, Melchiorri L, Stignani M, et al. HLA-G expression is a fundamental prerequisite to pregnancy. Hum Immunol,2007;68(4):244-250.
  • 5Paul P, Rouas-Freiss N, Moreau P, et al. HLA-G ,-E ,-F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression. Hum Immunol,2000;61 (11) :1171-1195.
  • 6Blaschitz A, Hutter H, Leitner V, et al. Reaction patterns of monoclonal antibodies to HLA-G in human tissues and on cell lines : a comparative study. Hum Immunol, 2000 ; 61 (11) : 1074- 1085.
  • 7Rabot M, Tabiasco J, Polgar B,et al. HLA class I /NK cell receptor interaction in early human decidua basalis: possible functional consequences. Chem Immunol Allergy, 2005 ; 89 : 72- 83.
  • 8Maier S, Grzeschik M, Weiss EH, et al. Implications of HLAE allele expression and different HLA-E ligand diversity for the regulation of NK cells. Hum Immunol, Z000; 61 (11): 1059- 1065.
  • 9Kanai T, Fujii T, Unno N, et al. Human leukocyte antigen-G- expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood. Am J Reprod Immunol,2001;45(2) :94-99.
  • 10Rieger L, Hofmeister V, Probe C, et al. Thl- and Th2-1ike cytokine production by first trimester decidual large granular lymphocytes is influenced by HLA-G and HLA-E. Mol Hum Reprod, 2002 ; 8 (3) : 255-261.

共引文献17

同被引文献113

  • 1Wegmann TG,Lin H,Guilbert L,et al. Bidirectional cytokine interac.tions in the maternal.fetal relationship: is successful pregnancy aTH2 phenomenon? [J] Immunol Today,1993,14(7):353-356.
  • 2Rizzo R,Vereammen M,van de Velde H,et al. The importance ofHLA.G expression in embryos,trophoblast cells,and embrtonic stemcells[J]. Cell Mol Life Sci,2011,68(3):341-352.
  • 3Chen BG,Xu DP,Lin A,et al. NK cytolysis is dependent on theproportion of HLA.G expression[J]. Hum Immunol,2013,74(3):286-289.
  • 4Zou Y,Li F,Hou W,et al. Manipulating the expression of chemokinereceptors enhances delivery and activity of cytokine induced killercells[J]. Br J Cancer,2014,110(8):1992-1999.
  • 5Morandi F,Rouas.Freiss N,Pistoia V. The emerging role of solubleHLA.G in the control of chemotaxi[J]. Cytokine Growth Factor Rev,2014,25(3):327-335.
  • 6Zhang WQ,Xu DP,Liu D,et al. HLA.G1 and HLA.G5 isoforms havean additive effect on NK cytolysis[J]. Hum Immunol, 2014,75(2):182-189.
  • 7Brown R,Kabani K,Favaloro J,et al. CD86+ or HLA.G+ can betransferred via trogotytosis from myeloma cells to T cells and are asso.ciated with poor prognosis[J]. Blood,2012,120(10):2055-2063.
  • 8Li MQ,Tang CL,Du MR,et al. CXCL12 controls over invasion oftrophoblasts via upregulationg CD82 expression in DSCs at maternal.fetal interface of huamanertly pregnancy in aparacrine manner[J].Int J Clin Exp Pathol,2014,4(3):276-286.
  • 9Guo PF, Du MR, Wu HX, et al. Thymic stromal lymphopoietin formtrophoblasts induces dendritic cell.mediate regulatory TH2 bias in thedeciduas during early gestation in humans [J]. Blood, 2010,116(112):2061-2069.
  • 10Hu Y, Dutz JP,MacCalman CD,et al. Decidual NK cell salterinvitrofirst trimester extravillouscytotrophoblast migration: a role forIFN.gamma[J].J Immunol,2006,177(12):8522-8530.

引证文献8

二级引证文献113

中国免疫学杂志
2015年 第5期

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