脑卒中后抑郁的相关因素分析

Research and analysis on the relatvie factors of post-stroke depression

目的 探讨卒中后抑郁（PSD）的相关因素,为早期预防及干预措施提供依据.方法 选取2011年6月～2013年7月在神经内科确诊的脑卒中患者140例进行调查,根据抑郁自评量表（SDS）、汉密尔顿抑郁量表（HAMD）得分情况分为抑郁组（SDS总分＞30分）和非抑郁组（SDS总分＜30分）.对PSD患者的性别、家庭关系、经济困难、丧偶、人格特征、社会支持、发病次数、病灶部位、病灶数目及基础疾病等相关因素进行分析.结果 140例脑卒中患者中出现PSD 58例,发生率41.43％.病灶位于大脑前部者抑郁组24例（41.1％）,非抑郁组20例（24.4％）;有多个病灶者抑郁组40例（69.0％）,非抑郁组33例（36.0％）,有心血管病史者抑郁组16例（27.6％）,非抑随组14例（17.1％）;有抑郁症病史者抑郁组7例（12.1％）,非抑郁组3例（2.4％）;有脑卒中病史者抑郁组23例（39.7％）,非抑郁组15例（18.3％）.两组在病灶部位、病灶数目、心血管病史、抑郁症史、脑卒中病史等方面比较,差异均有统计学意义（均P＜0.05）;与性别、年龄无明显相关性（P＞0.05）.结论 脑卒中后抑郁为多种因素共同作用的结果.

Objective To provide the basis for early prevention and intervening measure by studying the relative factors of post-stroke depression（PSD）. Methods 140 stroke patients were divided into depression group （SDS〉30） and non-depression group（SDS〈30） by Self-Rating Depression Seale（SDS） and Hamilton Depression Scale（HAMD）. Sexu- ality, family relationships, economic difficulties, widowhood, characters, social supports, the number of underlying dis- eases, the location of lesions, the number of lesions and other related factors with PSD patients were chosen to analysis. Results 58 cases appeared PSD in total 140 stroke patients. The occurrence rate was 41.43%. The Post-stroke Depres- sion was closely connected with the location of lesions, the number of lesions, cardiovascular disease histories, depression histories, and stroke histories. Conclusion Post-stroke Depression is the result of joint action of many factors.