噻托溴铵在中重度支气管哮喘治疗中的意义

The significance of tiotropium bromide in treatment of severe bronchial asthma

目的 探讨噻托溴铵在中重度支气管哮喘治疗中的意义.方法 选取2012年6月～2014年2月收治的中重度支气管哮喘患者110例为研究对象,根据治疗方式不同分为对照组与实验组各55例,对照组采用GINA规范性治疗,实验组在对照组基础上加噻托溴铵治疗.结果 实验组采用噻托溴铵治疗的效果较好,总有效率明显优于对照组（P＜0.05）.对患者进行ACT评分、吸入支气管扩张剂后FEV值、用力呼气峰速（PEF）值、用力呼吸中速流速值（FEF）以及每周使用急救药物次数与对照组比较,差异均有统计学意义（均P＜0.05）.结论 采用噻托溴铵治疗中重度支气管哮喘效果明显,且能够快速扩张患者的气道,有效改善患者的肺部功能,值得临床推广应用.

Objectives To explore the significance of tiotropium bromide in the treatment of severe bronchial asth- ma. Methods 110 severe bronchial asthma patients were selected in the clinical study. The control group used conven tional methods with aminophylline and the experimental group was treated with tiotropium bromide. Results The experi- mental group with tiotropium bromide achieved better effect after treatment, the quality of life of patients was improved, and the total efficience of experimental group was better than that of the control group. The differences of ACT socore, FEV value after receiving bronchodilator, peak expiratory flow （PEF） value, force expiratory flow（FEF）value and emergency medicine times between experimental group and control group were significant （P〈0.05）. Conclusion Using tiotropium bromide in the treatment of patients with severe bronchial asthma could improve the clinical effect.